Melanin-concentrating Hormone (MCH) Modifies Memory Retention in Rats

Overview

Journal Peptides

Specialty Biochemistry

Date 2000 Mar 4

PMID 10698129

Citations 27

Authors

M E Monzon

M M de Souza

L A Izquierdo

I Izquierdo

D M Barros

S R de Barioglio

Affiliations

Soon will be listed here.

Abstract

The purpose of the present study was to evaluate the possible effect of melanin-concentrating hormone (MCH) on learning and memory by using the one-trial step-down inhibitory avoidance test in rats. The peptide was infused into hippocampus, amygdala, and entorhinal cortex. MCH caused retrograde facilitation when given at 0 or 4 h post-training into hippocampus, but only at 0 h into amygdala. From these results, it seems that MCH modulates memory early after training by acting on both the amygdala and hippocampus and, 4 h after training, on the hippocampus.

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