Sonodynamic Therapy With Anticancer Micelles and High-Intensity Focused Ultrasound in Treatment of Canine Cancer

Overview

Journal Front Pharmacol

Date 2019 Jun 6

PMID 31164823

Citations 18

Authors

Yuki Horise

Masanori Maeda

Yoshiyuki Konishi

Jun Okamoto

Soko Ikuta

Yoshiharu Okamoto

Hiroshi Ishii

Shin Yoshizawa

Shinichiro Umemura

Tsuyoshi Ueyama

Satoshi Tamano

Atsushi Sofuni

Kazuhisa Takemae

Ken Masamune

Hiroshi Iseki

Nobuhiro Nishiyama

Kazunori Kataoka

Yoshihiro Muragaki

Affiliations

Soon will be listed here.

Abstract

Sonodynamic therapy (SDT) is a minimally invasive anticancer therapy involving a chemical sonosensitizer and high-intensity focused ultrasound (HIFU). SDT enables the reduction of drug dose and HIFU irradiation power compared to those of conventional monotherapies. In our previous study, mouse models of colon and pancreatic cancer were used to confirm the effectiveness of SDT vs. drug-only or HIFU-only therapy. To validate its usefulness, we performed a clinical trial of SDT using an anticancer micelle (NC-6300) and our HIFU system in four pet dogs with spontaneous tumors, including chondrosarcoma, osteosarcoma, hepatocellular cancer, and prostate cancer. The fact that no adverse events were observed, suggests the usefulness of SDT.

Citing Articles

[Utilizing Sonodynamic Therapy-Induced Pyroptosis for Liver Cancer Therapy].

Zhang N, Dai Z Sichuan Da Xue Xue Bao Yi Xue Ban. 2024; 55(5):1329-1335.

PMID: 39507962 PMC: 11536237. DOI: 10.12182/20240960210.

Functionalized Polymeric Micelles for Targeted Cancer Therapy: Steps from Conceptualization to Clinical Trials.

Serras A, Faustino C, Pinheiro L Pharmaceutics. 2024; 16(8).

PMID: 39204392 PMC: 11359152. DOI: 10.3390/pharmaceutics16081047.

A scientometric analysis of research trends, visualization, and emerging patterns in canine olfactory detection for cancer.

Espinoza-Carhuancho F, Mauricio F, Mauricio-Vilchez C, Galarza-Valencia D, Medina J, Pacheco-Mendoza J Vet World. 2024; 17(7):1430-1434.

PMID: 39185062 PMC: 11344121. DOI: 10.14202/vetworld.2024.1430-1434.

A review of the development of histotripsy for extremity tumor ablation with a canine comparative oncology model to inform human treatments.

Hay A, Ruger L, Hsueh A, Vickers E, Klahn S, Vlaisavljevich E Int J Hyperthermia. 2023; 40(1):2274802.

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Nanocarriers in Veterinary Medicine: A Challenge for Improving Osteosarcoma Conventional Treatments.

Sapino S, Chindamo G, Chirio D, Morel S, Peira E, Vercelli C Nanomaterials (Basel). 2022; 12(24).

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