The Prognostic Value of the Preoperative Albumin to Alkaline Phosphatase Ratio in Patients with Non-small Cell Lung Cancer After Surgery

Overview

Journal Thorac Cancer

Specialties Oncology
Pulmonary Medicine

Date 2019 Jun 5

PMID 31161711

Citations 14

Authors

Lianmin Zhang

Hua Zhang

Dongsheng Yue

Wei Wei

Yulong Chen

Xiaoliang Zhao

Jianquan Zhu

Bin Zhang

Zhenfa Zhang

Changli Wang

Affiliations

Soon will be listed here.

Abstract

Background: To assess the potential prognostic value of the albumin to alkaline phosphatase ratio (AAPR) in patients with non-small cell lung cancer (NSCLC) after surgery.

Methods: The log-rank and Kaplan-Meier analyses were performed to detect differences in survival levels between different groups. A model of Cox proportional hazards was used to perform univariate and multivariate survival analyses. Comparisons of receiver operating characteristic (ROC) curves and the likelihood ratio test (LRT) were also utilized to compare the prognostic abilities of different systems for overall survival (OS) prediction.

Results: The optimal cut-off value of the preoperative AAPR was 0.64. A decreased AAPR was associated with several clinicopathological and clinicolaboratory variables related to cancer progression. The preoperative AAPR of patients was positively correlated with the poor prognosis of NSCLC. In multivariate analyses, the preoperative AAPR was identified as an independent prognostic factor for disease-free survival (DFS; P = 0.001) and overall survival (OS; P = 0.003). The LRT showed that the AAPR tumor-node-metastasis (TNM) system presented a significantly larger χ value (112.4 vs. 89.2, respectively, P < 0.01) and a relatively smaller Akaike information criterion (AIC) value (2955 vs. 2977, respectively, P < 0.01) than the TNM staging system.

Conclusion: Preoperative AAPR was a potentially valuable prognostic factor in NSCLC patients who underwent surgery. Our results further showed that the AAPR-TNM system was superior to the current TNM staging system.

Citing Articles

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