Prognostic Value of Platelet to Lymphocyte Ratio in Non-small Cell Lung Cancer: a Systematic Review and Meta-analysis

Overview

Journal Sci Rep

Specialty Science

Date 2016 Mar 5

PMID 26939789

Citations 38

Authors

Hua Zhang

Liuwei Gao

Bin Zhang

Lianmin Zhang

Changli Wang

Affiliations

Soon will be listed here.

Abstract

The prognostic value of the platelet-to-lymphocyte ratio (PLR) in non-small cell lung cancer (NSCLC) remains controversial. We therefore conducted a meta-analysis of published studies to determine the prognostic value of PLR in NSCLC. A systematic search was performed in PubMed, Web of Science and Embase for relevant studies. The data and characteristics of each study were extracted, and the hazard ratio (HR) at a 95% confidence interval (CI) was calculated to estimate the effect. We also performed subgroup and meta-regression analyses. A total of 2,889 patients in 12 studies were enrolled in this meta-analysis, and the pooled HR of 1.492 (95% CI: 1.231-1.807, P < 0.001) indicated that patients with an elevated PLR are expected to have a shorter overall survival (OS) after treatment. This meta-analysis indicates that a high PLR might be a predictive factor of poor prognosis in NSCLC. Further large-cohort studies are needed to confirm these findings.

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References

Zhang L, Conejo-Garcia J, Katsaros D, Gimotty P, Massobrio M, Regnani G . Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med. 2003; 348(3):203-13. DOI: 10.1056/NEJMoa020177. View

Tierney J, Stewart L, Ghersi D, Burdett S, Sydes M . Practical methods for incorporating summary time-to-event data into meta-analysis. Trials. 2007; 8:16. PMC: 1920534. DOI: 10.1186/1745-6215-8-16. View

Koh C, Bhoo-Pathy N, Ng K, Jabir R, Tan G, See M . Utility of pre-treatment neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as prognostic factors in breast cancer. Br J Cancer. 2015; 113(1):150-8. PMC: 4647546. DOI: 10.1038/bjc.2015.183. View

Miyazaki T, Yamasaki N, Tsuchiya T, Matsumoto K, Kunizaki M, Taniguchi D . Inflammation-based scoring is a useful prognostic predictor of pulmonary resection for elderly patients with clinical stage I non-small-cell lung cancer. Eur J Cardiothorac Surg. 2014; 47(4):e140-5. DOI: 10.1093/ejcts/ezu514. View

Kawai O, Ishii G, Kubota K, Murata Y, Naito Y, Mizuno T . Predominant infiltration of macrophages and CD8(+) T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer. Cancer. 2008; 113(6):1387-95. DOI: 10.1002/cncr.23712. View

Kaya V, Yildirim M, Demirpence O, Yildiz M, Yalcin A . Prognostic significance of basic laboratory methods in non- small-cell-lung cancer. Asian Pac J Cancer Prev. 2013; 14(9):5473-6. DOI: 10.7314/apjcp.2013.14.9.5473. View

Mlecnik B, Tosolini M, Kirilovsky A, Berger A, Bindea G, Meatchi T . Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction. J Clin Oncol. 2011; 29(6):610-8. DOI: 10.1200/JCO.2010.30.5425. View

Sanchez-Lara K, Turcott J, Juarez E, Guevara P, Nunez-Valencia C, Onate-Ocana L . Association of nutrition parameters including bioelectrical impedance and systemic inflammatory response with quality of life and prognosis in patients with advanced non-small-cell lung cancer: a prospective study. Nutr Cancer. 2012; 64(4):526-34. DOI: 10.1080/01635581.2012.668744. View

Wagner D . New links between inflammation and thrombosis. Arterioscler Thromb Vasc Biol. 2005; 25(7):1321-4. DOI: 10.1161/01.ATV.0000166521.90532.44. View

10.

DerSimonian R, Laird N . Meta-analysis in clinical trials. Control Clin Trials. 1986; 7(3):177-88. DOI: 10.1016/0197-2456(86)90046-2. View

11.

Labelle M, Begum S, Hynes R . Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell. 2011; 20(5):576-90. PMC: 3487108. DOI: 10.1016/j.ccr.2011.09.009. View

12.

Cannon N, Meyer J, Iyengar P, Ahn C, Westover K, Choy H . Neutrophil-lymphocyte and platelet-lymphocyte ratios as prognostic factors after stereotactic radiation therapy for early-stage non-small-cell lung cancer. J Thorac Oncol. 2014; 10(2):280-5. DOI: 10.1097/JTO.0000000000000399. View

13.

Senzel L, Gnatenko D, Bahou W . The platelet proteome. Curr Opin Hematol. 2009; 16(5):329-33. PMC: 2883290. DOI: 10.1097/MOH.0b013e32832e9dc6. View

14.

Hanahan D, Weinberg R . Hallmarks of cancer: the next generation. Cell. 2011; 144(5):646-74. DOI: 10.1016/j.cell.2011.02.013. View

15.

Wakefield L, Smith D, Flanders K, Sporn M . Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences. J Biol Chem. 1988; 263(16):7646-54. View

16.

Zhang T, Jiang Y, Qu X, Shen H, Liu Q, Du J . Evaluation of preoperative hematologic markers as prognostic factors and establishment of novel risk stratification in resected pN0 non-small-cell lung cancer. PLoS One. 2014; 9(10):e111494. PMC: 4216075. DOI: 10.1371/journal.pone.0111494. View

17.

Stone R, Nick A, McNeish I, Balkwill F, Han H, Bottsford-Miller J . Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med. 2012; 366(7):610-8. PMC: 3296780. DOI: 10.1056/NEJMoa1110352. View

18.

Aliustaoglu M, Bilici A, Ustaalioglu B, Konya V, Gucun M, Seker M . The effect of peripheral blood values on prognosis of patients with locally advanced gastric cancer before treatment. Med Oncol. 2009; 27(4):1060-5. DOI: 10.1007/s12032-009-9335-4. View

19.

Kwon H, Kim S, Oh S, Lee S, Lee J, Choi H . Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in patients with operable colorectal cancer. Biomarkers. 2012; 17(3):216-22. DOI: 10.3109/1354750X.2012.656705. View

20.

Zhang H, Xia H, Zhang L, Zhang B, Yue D, Wang C . Clinical significance of preoperative neutrophil-lymphocyte vs platelet-lymphocyte ratio in primary operable patients with non-small cell lung cancer. Am J Surg. 2015; 210(3):526-35. DOI: 10.1016/j.amjsurg.2015.03.022. View