Prevalence and Related Factors of Sarcopenia in Newly Diagnosed Cancer Patients

Overview

Journal Support Care Cancer

Specialties Critical Care
Oncology

Date 2019 Jun 5

PMID 31161438

Citations 11

Authors

Utku Oflazoglu

Ahmet Alacacioglu

Umut Varol

Yuksel Kucukzeybek

Tarik Salman

Halil Taskaynatan

Yasar Yildiz

Ozlem Ozdemir

MustafaOktay Tarhan

Affiliations

Soon will be listed here.

Abstract

Introduction: Sarcopenia is defined as the loss of muscle mass and muscular functioning. Although sarcopenia prevalence is highly variable in the literature, pre-chemotherapy sarcopenia prevalence was not well studied in newly diagnosed cancer patients. In this context, the present study aims to determine the prevalence of sarcopenia and its related factors in this population.

Material And Methods: Prospectively, newly diagnosed cancer patients were evaluated for body composition measurement and muscle strength by employing the bioelectric impedance analysis method and handgrip dynamometer tool.

Results: A total of 461 patients were included in the study. The median age of patients was 59 years (range 18-83) and 258 patients (56%) were women. Sarcopenia was present in 77 patients (16.7%) and was at significantly higher frequencies in men (p = 0.015), advanced age (≥ 65 years, p = 0.014), lower body mass index (BMI < 25, p = < 0.001), and poor performance status (ECOG status > 0, p = 0.026). In multivariate analyses, advanced age (over 65 years), gender (men), and lower body mass index (BMI < 25) were significantly associated with sarcopenia (p values 0.033, < 0.001, and < 0.001, respectively).

Conclusions: Our study is the first prevalence study conducted with bioelectric impedance analysis on Turkish cancer patients and sarcopenia was detected to be notably prevalent among our patients with newly diagnosed cancer. Given the likely negative outcomes of sarcopenia reported in the literature (treatment failure, increased complications, and impaired survival), it is important to know the presence of sarcopenia before treatment and take preventive precautions.

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