Prevalence of Sarcopenia and Relevance of Body Composition, Physiological Function, Fatigue, and Health-related Quality of Life in Patients Before Allogeneic Hematopoietic Stem Cell Transplantation

Overview

Journal Support Care Cancer

Specialties Critical Care
Oncology

Date 2012 Apr 25

PMID 22526152

Citations 53

Authors

Shinichiro Morishita

Katsuji Kaida

Takashi Tanaka

Yusuke Itani

Kazuhiro Ikegame

Masaya Okada

Shinichi Ishii

Norihiko Kodama

Hiroyasu Ogawa

Kazuhisa Domen

Affiliations

Soon will be listed here.

Abstract

Purpose: Cachexia in patients with hematological malignancies is often related to sarcopenia. We believe that allogeneic hematopoietic stem cell transplant (allo-HSCT) patients often exhibit sarcopenia prior to transplantation. Here, we aimed to investigate the prevalence of sarcopenia and its relationship with body composition, physiological function, nutrition, fatigue, and health-related quality of life (QOL) in patients before allo-HSCT. We further investigated the confounding factors associated with sarcopenia.

Methods: We included 164 patients with allo-HSCT in this study. Body composition, handgrip, knee extensor strength, and 6-min walk test were evaluated. Furthermore, fatigue, nutritional status, and health-related QOL were also evaluated.

Results: Eighty-three patients (50.6 %) enrolled in our study had sarcopenia prior to allo-HSCT. Patients with sarcopenia experienced decreased muscular strength and increased fatigue compared with patients without sarcopenia (p < 0.05). Patients with sarcopenia showed significantly lower scores in physical functioning, bodily pain, and vitality in health-related QOL than those without sarcopenia. Multivariate regression analysis revealed that only gender and body mass index were significantly related to sarcopenia (gender, odds ratio, 3.09; body mass index, odds ratio, 0.70; p < 0.01).

Conclusions: Sarcopenia is common in patients before allo-HSCT and related to low muscle strength, fatigue, and health-related QOL. Male patients may be more susceptible to sarcopenia than female patients before allo-HSCT. Further study of rehabilitation with gender insight is warranted for patients receiving allo-HSCT.

Citing Articles

Factors affecting pretransplant muscle strength in allogeneic stem cell transplant candidates prior transplantation.

Limbach M, Kuehl R, Koeppel M, Dreger P, Luft T, Bohus M Support Care Cancer. 2025; 33(2):89.

PMID: 39794666 PMC: 11723852. DOI: 10.1007/s00520-024-09140-8.

Head and Neck Cancer and Sarcopenia: An Integrative Clinical and Functional Review.

Endo K, Ichinose M, Kobayashi E, Ueno T, Hirai N, Nakanishi Y Cancers (Basel). 2024; 16(20).

PMID: 39456555 PMC: 11506384. DOI: 10.3390/cancers16203460.

Changes in nutritional status and associations with physical and clinical outcomes in acute myeloid leukemia patients during intensive chemotherapy.

van Lieshout R, Tick L, Beckers E, Biesbroek W, Dieleman J, Dijkstra M Eur J Clin Nutr. 2024; 78(12):1082-1094.

PMID: 39127840 DOI: 10.1038/s41430-024-01488-8.

Changes in skeletal muscle function during chemotherapy and related factors in patients with acute leukemia.

Terao Y, Nakayama Y, Abo M, Otobe Y, Suzuki M, Kojima I Support Care Cancer. 2024; 32(8):512.

PMID: 39001992 DOI: 10.1007/s00520-024-08729-3.

Assessment of rehabilitation practices during hematopoietic stem cell transplantation in the United States: a survey.

Leite V, Oza S, Parke S, Barksdale T, Herbert A, Bansal V Rehabil Oncol. 2024; 42(2):91-99.

PMID: 38912164 PMC: 11192508. DOI: 10.1097/01.REO.0000000000000363.

References

Janssen I, Heymsfield S, Ross R . Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc. 2002; 50(5):889-96. DOI: 10.1046/j.1532-5415.2002.50216.x. View

Chien M, Huang T, Wu Y . Prevalence of sarcopenia estimated using a bioelectrical impedance analysis prediction equation in community-dwelling elderly people in Taiwan. J Am Geriatr Soc. 2008; 56(9):1710-5. DOI: 10.1111/j.1532-5415.2008.01854.x. View

Piper B, Dibble S, Dodd M, Weiss M, Slaughter R, Paul S . The revised Piper Fatigue Scale: psychometric evaluation in women with breast cancer. Oncol Nurs Forum. 1998; 25(4):677-84. View

Bosaeus I, Daneryd P, Svanberg E, Lundholm K . Dietary intake and resting energy expenditure in relation to weight loss in unselected cancer patients. Int J Cancer. 2001; 93(3):380-3. DOI: 10.1002/ijc.1332. View

Lieffers J, Mourtzakis M, Hall K, McCargar L, Prado C, Baracos V . A viscerally driven cachexia syndrome in patients with advanced colorectal cancer: contributions of organ and tumor mass to whole-body energy demands. Am J Clin Nutr. 2009; 89(4):1173-9. PMC: 2667460. DOI: 10.3945/ajcn.2008.27273. View

Molassiotis A . Anorexia and weight loss in long-term survivors of haematological malignancies. J Clin Nurs. 2003; 12(6):925-7. DOI: 10.1046/j.1365-2702.2003.00778.x. View

Prado C, Baracos V, McCargar L, Mourtzakis M, Mulder K, Reiman T . Body composition as an independent determinant of 5-fluorouracil-based chemotherapy toxicity. Clin Cancer Res. 2007; 13(11):3264-8. DOI: 10.1158/1078-0432.CCR-06-3067. View

Prado C, Lieffers J, McCargar L, Reiman T, Sawyer M, Martin L . Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet Oncol. 2008; 9(7):629-35. DOI: 10.1016/S1470-2045(08)70153-0. View

Sciurba F, Criner G, Lee S, Mohsenifar Z, Shade D, Slivka W . Six-minute walk distance in chronic obstructive pulmonary disease: reproducibility and effect of walking course layout and length. Am J Respir Crit Care Med. 2003; 167(11):1522-7. DOI: 10.1164/rccm.200203-166OC. View

10.

Lau A, Chang C, Tai J, Eremenco S, Liang R, Lie A . Translation and validation of the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) Version 4 quality of life instrument into traditional Chinese. Bone Marrow Transplant. 2002; 29(1):41-9. DOI: 10.1038/sj.bmt.1703313. View

11.

Morishita S, Kaida K, Ikegame K, Yoshihara S, Taniguchi K, Okada M . Impaired physiological function and health-related QOL in patients before hematopoietic stem-cell transplantation. Support Care Cancer. 2011; 20(4):821-9. DOI: 10.1007/s00520-011-1156-2. View

12.

Kull M, Kallikorm R, Lember M . Impact of a new sarco-osteopenia definition on health-related quality of life in a population-based cohort in Northern Europe. J Clin Densitom. 2011; 15(1):32-8. DOI: 10.1016/j.jocd.2011.08.007. View

13.

Syrjala K, Stover A, Yi J, Artherholt S, Abrams J . Measuring social activities and social function in long-term cancer survivors who received hematopoietic stem cell transplantation. Psychooncology. 2009; 19(5):462-71. PMC: 3114555. DOI: 10.1002/pon.1572. View

14.

Muscaritoli M, Anker S, Argiles J, Aversa Z, Bauer J, Biolo G . Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics". Clin Nutr. 2010; 29(2):154-9. DOI: 10.1016/j.clnu.2009.12.004. View

15.

Prado C, Baracos V, McCargar L, Reiman T, Mourtzakis M, Tonkin K . Sarcopenia as a determinant of chemotherapy toxicity and time to tumor progression in metastatic breast cancer patients receiving capecitabine treatment. Clin Cancer Res. 2009; 15(8):2920-6. DOI: 10.1158/1078-0432.CCR-08-2242. View

16.

. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002; 166(1):111-7. DOI: 10.1164/ajrccm.166.1.at1102. View

17.

Chien M, Kuo H, Wu Y . Sarcopenia, cardiopulmonary fitness, and physical disability in community-dwelling elderly people. Phys Ther. 2010; 90(9):1277-87. DOI: 10.2522/ptj.20090322. View

18.

Baumgartner R, Koehler K, Gallagher D, Romero L, Heymsfield S, Ross R . Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol. 1998; 147(8):755-63. DOI: 10.1093/oxfordjournals.aje.a009520. View

19.

Kilgour R, Vigano A, Trutschnigg B, Hornby L, Lucar E, Bacon S . Cancer-related fatigue: the impact of skeletal muscle mass and strength in patients with advanced cancer. J Cachexia Sarcopenia Muscle. 2011; 1(2):177-185. PMC: 3060645. DOI: 10.1007/s13539-010-0016-0. View

20.

Guimaraes F, Dos Santos M, Oliveira E . Quality of life of patients with autoimmune diseases submitted to bone marrow transplantation: a longitudinal study. Rev Lat Am Enfermagem. 2008; 16(5):856-63. DOI: 10.1590/s0104-11692008000500010. View