A Self-Adhesive Elastomeric Wound Scaffold for Sensitive Adhesion to Tissue

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2019 Jun 5

PMID 31159156

Citations 5

Authors

Silviya Boyadzhieva

Katharina Sorg

Martin Danner

Sarah C L Fischer

Rene Hensel

Bernhard Schick

Gentiana Wenzel

Eduard Arzt

Klaus Kruttwig

Affiliations

Soon will be listed here.

Abstract

Pressure sensitive adhesives based on silicone materials are used particularly for skin adhesion, e.g., the fixation of electrocardiogram (ECG) electrodes or wound dressings. However, adhesion to sensitive tissue structures is not sufficiently addressed due to the risk of damage or rupture. We propose an approach in which a poly-(dimethylsiloxane) (PDMS)-based soft skin adhesive (SSA) acts as cellular scaffold for wound healing. Due to the intrinsically low surface free energy of silicone elastomers, functionalization strategies are needed to promote the attachment and spreading of eukaryotic cells. In the present work, the effect of physical adsorption of three different proteins on the adhesive properties of the soft skin adhesive was investigated. Fibronectin adsorption slightly affects adhesion but significantly improves the cellular interaction of L929 murine fibroblasts with the polymeric surface. Composite films were successfully attached to explanted tympanic membranes. This demonstrates the potential of protein functionalized SSA to act as an adhesive scaffold in delicate biomedical applications.

Citing Articles

Film-Terminated Fibrillar Microstructures with Improved Adhesion on Skin-like Surfaces.

Moreira Lana G, Zhang X, Muller C, Hensel R, Arzt E ACS Appl Mater Interfaces. 2022; 14(41):46239-46251.

PMID: 36195314 PMC: 9586108. DOI: 10.1021/acsami.2c12663.

Multiscale Soft Surface Instabilities for Adhesion Enhancement.

Mohanan V, Mak H, Gurung N, Xu Q Materials (Basel). 2022; 15(3).

PMID: 35160799 PMC: 8836914. DOI: 10.3390/ma15030852.

Synthesis, Characterisation and Antibacterial Properties of Silicone-Silver Thin Film for the Potential of Medical Device Applications.

Aizamddin M, Mahat M, Zainal Ariffin Z, Samsudin I, Razali M, Amir M Polymers (Basel). 2021; 13(21).

PMID: 34771378 PMC: 8588057. DOI: 10.3390/polym13213822.

Optoacoustically induced auditory brainstem responses in the mouse model enhanced through an absorbing film.

Sorg K, Heimann L, Moreira Lana G, Langenbucher A, Schick B, Arzt E J Biomed Opt. 2021; 26(9).

PMID: 34480448 PMC: 8414560. DOI: 10.1117/1.JBO.26.9.098001.

Adhesive Tissue Engineered Scaffolds: Mechanisms and Applications.

Chen S, Gil C, Ning L, Jin L, Perez L, Kabboul G Front Bioeng Biotechnol. 2021; 9:683079.

PMID: 34354985 PMC: 8329531. DOI: 10.3389/fbioe.2021.683079.

References

Bhati R, Mukherjee D, McCarthy K, Rogers S, Smith D, Shalaby S . The growth of chondrocytes into a fibronectin-coated biodegradable scaffold. J Biomed Mater Res. 2001; 56(1):74-82. DOI: 10.1002/1097-4636(200107)56:1<74::aid-jbm1070>3.0.co;2-m. View

Cunningham J, Nikolovski J, Linderman J, Mooney D . Quantification of fibronectin adsorption to silicone-rubber cell culture substrates. Biotechniques. 2002; 32(4):876, 878, 880 passim. DOI: 10.2144/02324rr05. View

Ai H, Lvov Y, Mills D, Jennings M, Alexander J, Jones S . Coating and selective deposition of nanofilm on silicone rubber for cell adhesion and growth. Cell Biochem Biophys. 2003; 38(2):103-14. DOI: 10.1385/CBB:38:2:103. View

Bundy K, Schlegel U, Rahn B, Geret V, Perren S . An improved peel test method for measurement of adhesion to biomaterials. J Mater Sci Mater Med. 2004; 11(8):517-21. DOI: 10.1023/a:1008965926086. View

Toworfe G, Composto R, Adams C, Shapiro I, Ducheyne P . Fibronectin adsorption on surface-activated poly(dimethylsiloxane) and its effect on cellular function. J Biomed Mater Res A. 2004; 71(3):449-61. DOI: 10.1002/jbm.a.30164. View

Peterson S, McDonald A, Gourley P, Sasaki D . Poly(dimethylsiloxane) thin films as biocompatible coatings for microfluidic devices: cell culture and flow studies with glial cells. J Biomed Mater Res A. 2004; 72(1):10-8. DOI: 10.1002/jbm.a.30166. View

Gun Park D, Shin S, Kang S, Kim Y . Development of flexible self adhesive patch for professional heat stress monitoring service. Conf Proc IEEE Eng Med Biol Soc. 2007; 2005:3789-92. DOI: 10.1109/IEMBS.2005.1617309. View

Yamazoe H, Tanabe T . Preparation of water-insoluble albumin film possessing nonadherent surface for cells and ligand binding ability. J Biomed Mater Res A. 2007; 86(1):228-34. DOI: 10.1002/jbm.a.31654. View

Bernards M, Qin C, Jiang S . MC3T3-E1 cell adhesion to hydroxyapatite with adsorbed bone sialoprotein, bone osteopontin, and bovine serum albumin. Colloids Surf B Biointerfaces. 2008; 64(2):236-47. PMC: 2490605. DOI: 10.1016/j.colsurfb.2008.01.025. View

10.

Jonsson C, Aronsson M, Rundstrom G, Pettersson C, Mendel-Hartvig I, Bakker J . Silane-dextran chemistry on lateral flow polymer chips for immunoassays. Lab Chip. 2008; 8(7):1191-7. DOI: 10.1039/b800297e. View

11.

Comelles J, Estevez M, Martinez E, Samitier J . The role of surface energy of technical polymers in serum protein adsorption and MG-63 cells adhesion. Nanomedicine. 2009; 6(1):44-51. DOI: 10.1016/j.nano.2009.05.006. View

12.

Tan S, Nguyen N, Chua Y, Kang T . Oxygen plasma treatment for reducing hydrophobicity of a sealed polydimethylsiloxane microchannel. Biomicrofluidics. 2010; 4(3):32204. PMC: 2967237. DOI: 10.1063/1.3466882. View

13.

Kwak M, Jeong H, Suh K . Rational design and enhanced biocompatibility of a dry adhesive medical skin patch. Adv Mater. 2011; 23(34):3949-53. DOI: 10.1002/adma.201101694. View

14.

Tersteeg C, Roest M, Mak-Nienhuis E, Ligtenberg E, Hoefer I, de Groot P . A fibronectin-fibrinogen-tropoelastin coating reduces smooth muscle cell growth but improves endothelial cell function. J Cell Mol Med. 2012; 16(9):2117-26. PMC: 3822982. DOI: 10.1111/j.1582-4934.2011.01519.x. View

15.

Kroner E, Blau J, Arzt E . Note: An adhesion measurement setup for bioinspired fibrillar surfaces using flat probes. Rev Sci Instrum. 2012; 83(1):016101. DOI: 10.1063/1.3675888. View

16.

Horvathy D, Vacz G, Cselenyak A, Weszl M, Kiss L, Lacza Z . Albumin-coated bioactive suture for cell transplantation. Surg Innov. 2012; 20(3):249-55. DOI: 10.1177/1553350612451353. View

17.

Davis C, Martina D, Creton C, Lindner A, Crosby A . Enhanced adhesion of elastic materials to small-scale wrinkles. Langmuir. 2012; 28(42):14899-908. DOI: 10.1021/la302314z. View

18.

Hong P, Bance M, Gratzer P . Repair of tympanic membrane perforation using novel adjuvant therapies: a contemporary review of experimental and tissue engineering studies. Int J Pediatr Otorhinolaryngol. 2012; 77(1):3-12. DOI: 10.1016/j.ijporl.2012.09.022. View

19.

Kalaskar D, Downes J, Murray P, Edgar D, Williams R . Characterization of the interface between adsorbed fibronectin and human embryonic stem cells. J R Soc Interface. 2013; 10(83):20130139. PMC: 3645423. DOI: 10.1098/rsif.2013.0139. View

20.

Beal J, Bubendorfer A, Kemmitt T, Hoek I, Arnold W . A rapid, inexpensive surface treatment for enhanced functionality of polydimethylsiloxane microfluidic channels. Biomicrofluidics. 2013; 6(3):36503. PMC: 3423308. DOI: 10.1063/1.4740232. View