Ethnogeographic Prevalence and Implications of the 677C>T and 1298A>C Polymorphisms in US Primary Care Populations

Overview

Journal Biomark Med

Specialties Biochemistry
General Medicine

Date 2019 Jun 4

PMID 31157538

Citations 12

Authors

James S Graydon

Karla Claudio

Seth Baker

Mohan Kocherla

Mark Ferreira

Abiel Roche-Lima

Jovaniel Rodriguez-Maldonado

Jorge Duconge

Gualberto Ruano

Affiliations

Soon will be listed here.

Abstract

Variants of the gene have been associated with a wide range of diseases. The present study analyzed data from clinical genotyping of and in 1405 patients in urban primary care settings. Striking differences in ethnogeographic frequencies of polymorphisms were observed. African-Americans appear to be protected from MTHFR deficiency. Hispanics and Caucasians may be at elevated risk due to increased frequencies of and , respectively. Individuals carrying mutations for both genes were rare and doubly homozygous mutants were absent, suggesting the is extremely rare in the greater population. The results suggest multilocus genotyping may yield deeper insight into the ethnogeographic association between variants and disease.

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