Jorge Duconge
Overview
Explore the profile of Jorge Duconge including associated specialties, affiliations and a list of published articles.
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Articles
94
Citations
584
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Recent Articles
1.
Yang G, Gonzalez P, Monero M, Carrasquillo K, Renta J, Hernandez-Suarez D, et al.
NPJ Genom Med
. 2025 Mar;
10(1):20.
PMID: 40055373
High on-treatment platelet reactivity (HTPR) with clopidogrel predicts ischemic events in adults with coronary artery disease, and while HTPR varies by ethnicity, no genome-wide association study (GWAS) of clopidogrel response...
2.
A review of precision medicine in developing pharmaceutical products: Perspectives and opportunities
Martinez-Jimenez J, Sathisaran I, Reyes Figueroa F, Reyes S, Lopez-Nieves M, Vlaar C, et al.
Int J Pharm
. 2024 Dec;
670:125070.
PMID: 39689830
Over the next decade, Precision Medicine (PM) is poised to become the standard of care in pharmaceutical therapy, necessitating a fundamental transformation in the design and development of innovative custom-made...
3.
Monero-Paredes M, Santiago E, Carrasquillo-Carrion K, Renta J, Rogozin I, Roche-Lima A, et al.
Int J Mol Sci
. 2024 Oct;
25(19).
PMID: 39408985
Clopidogrel, a prescription drug to reduce ischemic events in cardiovascular patients, has been extensively studied in mostly European individuals but not among Caribbean Hispanics. This study evaluated the low abundance...
4.
Nunez-Medina H, Monero M, Torres L, Leal E, Gonzalez-Sepulveda L, Mayor A, et al.
BMJ Open
. 2024 Sep;
14(9):e084119.
PMID: 39242160
Objectives: To assess whether genotype-guided selection of oral antiplatelet drugs using a clinical decision support (CDS) algorithm reduces the rate of major adverse cardiovascular and cerebrovascular events (MACCEs) among Caribbean...
5.
Zubiaur P, Rodriguez-Antona C, Boone E, Daly A, Tsermpini E, Khasawneh L, et al.
Clin Pharmacol Ther
. 2024 Aug;
116(4):963-975.
PMID: 39135485
The Pharmacogene Variation Consortium (PharmVar) serves as a global repository providing star (*) allele nomenclature for the polymorphic human CYP4F2 gene. CYP4F2 genetic variation impacts the metabolism of vitamin K,...
6.
Morales P, Santiago L, Rosario J, Garcia-Fragoso L, Duconge J, Perez N, et al.
P R Health Sci J
. 2024 Mar;
43(1):25-31.
PMID: 38512758
Objective: Neonatal abstinence syndrome (NAS) is a set of drug withdrawal symptoms suffered by neonates exposed to drugs in utero. Several studies have widely described NAS incidence and treatment approach;...
7.
Nunez-Medina H, Monero M, Torres L, Leal E, Gonzalez-Sepulveda L, Mayor A, et al.
medRxiv
. 2023 Dec;
PMID: 38106133
Background: After percutaneous coronary intervention (PCI), clopidogrel resistant patients are at an increased risk of major adverse cardiovascular and cerebrovascular events (MACCEs). We aimed to assess whether genotype-guided selection of...
8.
Rodriguez-Fernandez K, Reynaldo-Fernandez G, Reyes-Gonzalez S, de Las Barreras C, Rodriguez-Vera L, Vlaar C, et al.
Biomed Pharmacother
. 2023 Dec;
170:115977.
PMID: 38056237
Warfarin, an oral anticoagulant, has been used for decades to prevent thromboembolic events. The complex interplay between CYP2C9 and VKORC1 genotypes on warfarin PK and PD properties is not fully...
9.
Yang G, Gonzalez P, Monero M, Carrasquillo K, Renta J, Hernandez-Suarez D, et al.
medRxiv
. 2023 Oct;
PMID: 37873439
Background: High on-treatment platelet reactivity (HTPR) with clopidogrel is predictive of ischemic events in adults with coronary artery disease. Despite strong data suggesting HTPR varies with ethnicity, including clinical and...
10.
Monero-Paredes M, Feliu-Maldonado R, Carrasquillo-Carrion K, Gonzalez P, Rogozin I, Roche-Lima A, et al.
Genes (Basel)
. 2023 Sep;
14(9).
PMID: 37761953
Cardiovascular disease (CVD) is one of the leading causes of death in Puerto Rico, where clopidogrel is commonly prescribed to prevent ischemic events. Genetic contributors to both a poor clopidogrel...