Potential TSPO Ligand and Photooxidation Quencher Isorenieratene from Arctic Ocean Sp. B7740

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2019 Jun 1

PMID 31146377

Citations 6

Authors

Yashu Chen

Mengyao Guo

Jifang Yang

Jigang Chen

Bijun Xie

Zhida Sun

Affiliations

Soon will be listed here.

Abstract

Due to its special aromatic structure, isorenieratene is thought to be an active natural antioxidant and photo/UV damage inhibitor. In this work, isorenieratene that was extracted from Rhodococcus sp. B7740 isolated from the Arctic Ocean, showed excellent scavenging ability of both singlet oxygen and hydroxyl radical in the UVB-induced auto-oxidation process using the EPR method. Within an ARPE-19 cell model damaged by UVB radiation, isorenieratene showed fine protective effects (1.13 ± 0.03 fold) compared with macular xanthophylls (MXs) through upregulating of . The molecular docking was firstly performed to investigate the interaction of isorenieratene with TSPO as a special ligand. Results showed isorenieratene might form a better binding conformation (S-score -8.5438) than MXs and indicate that isorenieratene not only can function as a direct antioxidant but also activate in ARPE-19 cells. Thus, isorenieratene might ease the UV-related damages including age-related macular degeneration (AMD).

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References

Bone R, Landrum J, Dixon Z, Chen Y, Llerena C . Lutein and zeaxanthin in the eyes, serum and diet of human subjects. Exp Eye Res. 2000; 71(3):239-45. DOI: 10.1006/exer.2000.0870. View

van der Spoel D, Lindahl E, Hess B, Groenhof G, Mark A, Berendsen H . GROMACS: fast, flexible, and free. J Comput Chem. 2005; 26(16):1701-18. DOI: 10.1002/jcc.20291. View

Youn H, Bantseev V, Bols N, Cullen A, Sivak J . In vitro assays for evaluating the ultraviolet B-induced damage in cultured human retinal pigment epithelial cells. J Photochem Photobiol B. 2007; 88(1):21-8. DOI: 10.1016/j.jphotobiol.2007.04.012. View

Kerr J, McElroy C . Evidence for large upward trends of ultraviolet-B radiation linked to ozone depletion. Science. 1993; 262(5136):1032-4. DOI: 10.1126/science.262.5136.1032. View

Martin H, Kock S, Scherrers R, Lutter K, Wagener T, Hundsdorfer C . 3,3'-Dihydroxyisorenieratene, a natural carotenoid with superior antioxidant and photoprotective properties. Angew Chem Int Ed Engl. 2008; 48(2):400-3. DOI: 10.1002/anie.200803668. View

Fuciman M, Chabera P, Zupcanova A, Hribek P, Arellano J, Vacha F . Excited state properties of aryl carotenoids. Phys Chem Chem Phys. 2010; 12(13):3112-20. DOI: 10.1039/b921384h. View

Subczynski W, Wisniewska A, Widomska J . Location of macular xanthophylls in the most vulnerable regions of photoreceptor outer-segment membranes. Arch Biochem Biophys. 2010; 504(1):61-6. PMC: 2957566. DOI: 10.1016/j.abb.2010.05.015. View

Richer S, Stiles W, Graham-Hoffman K, Levin M, Ruskin D, Wrobel J . Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function in patients with atrophic age-related macular degeneration: the Zeaxanthin and Visual Function Study (ZVF) FDA IND #78, 973. Optometry. 2011; 82(11):667-680.e6. DOI: 10.1016/j.optm.2011.08.008. View

Chou W, Wang Y, Chen K, Wu J, Liang C, Juo S . Tannic acid suppresses ultraviolet B-induced inflammatory signaling and complement factor B on human retinal pigment epithelial cells. Cell Immunol. 2011; 273(1):79-84. DOI: 10.1016/j.cellimm.2011.11.003. View

10.

Yin J, Andersen M, Thomsen M, Skibsted L, Hedegaard R . Formation of radicals during heating lysine and glucose in solution with an intermediate water activity. Free Radic Res. 2013; 47(8):643-50. DOI: 10.3109/10715762.2013.812206. View

11.

Jaremko L, Jaremko M, Giller K, Becker S, Zweckstetter M . Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. Science. 2014; 343(6177):1363-6. PMC: 5650047. DOI: 10.1126/science.1248725. View

12.

Wong W, Su X, Li X, Cheung C, Klein R, Cheng C . Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health. 2014; 2(2):e106-16. DOI: 10.1016/S2214-109X(13)70145-1. View

13.

Sur A, Kesaraju S, Prentice H, Ayyanathan K, Baronas-Lowell D, Zhu D . Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-α. Proc Natl Acad Sci U S A. 2014; 111(47):16754-9. PMC: 4250171. DOI: 10.1073/pnas.1419576111. View

14.

Wu Q, Li S, Li X, Sui Y, Yang Y, Dong L . Inhibition of Advanced Glycation Endproduct Formation by Lotus Seedpod Oligomeric Procyanidins through RAGE-MAPK Signaling and NF-κB Activation in High-Fat-Diet Rats. J Agric Food Chem. 2015; 63(31):6989-98. DOI: 10.1021/acs.jafc.5b01082. View

15.

Silvan J, Reguero M, de Pascual-Teresa S . A protective effect of anthocyanins and xanthophylls on UVB-induced damage in retinal pigment epithelial cells. Food Funct. 2016; 7(2):1067-76. DOI: 10.1039/c5fo01368b. View

16.

Zareba M, Widomska J, Burke J, Subczynski W . Nitroxide free radicals protect macular carotenoids against chemical destruction (bleaching) during lipid peroxidation. Free Radic Biol Med. 2016; 101:446-454. PMC: 5154825. DOI: 10.1016/j.freeradbiomed.2016.11.012. View

17.

Frede K, Ebert F, Kipp A, Schwerdtle T, Baldermann S . Lutein Activates the Transcription Factor Nrf2 in Human Retinal Pigment Epithelial Cells. J Agric Food Chem. 2017; 65(29):5944-5952. DOI: 10.1021/acs.jafc.7b01929. View

18.

Chen Y, Xie B, Yang J, Chen J, Sun Z . Identification of microbial carotenoids and isoprenoid quinones from Rhodococcus sp. B7740 and its stability in the presence of iron in model gastric conditions. Food Chem. 2017; 240:204-211. DOI: 10.1016/j.foodchem.2017.06.067. View

19.

Biswas L, Zhou X, Dhillon B, Graham A, Shu X . Retinal pigment epithelium cholesterol efflux mediated by the 18 kDa translocator protein, TSPO, a potential target for treating age-related macular degeneration. Hum Mol Genet. 2017; 26(22):4327-4339. DOI: 10.1093/hmg/ddx319. View

20.

Barron A, Ji B, Kito S, Suhara T, Higuchi M . Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male. Biochem J. 2017; 475(1):75-85. DOI: 10.1042/BCJ20170645. View