Galleria Mellonella As a Consolidated in Vivo Model Hosts: New Developments in Antibacterial Strategies and Novel Drug Testing

Overview

Journal Virulence

Specialty Microbiology

Date 2019 May 31

PMID 31142220

Citations 73

Authors

Marco Alfio Cutuli

Giulio Petronio Petronio

Franca Vergalito

Irene Magnifico

Laura Pietrangelo

Noemi Venditti

Roberto Di Marco

Affiliations

Soon will be listed here.

Abstract

A greater ethical conscience, new global rules and a modified perception of ethical consciousness entail a more rigorous control on utilizations of vertebrates for studies. To cope with this new scenario, numerous alternatives to rodents have been proposed. Among these, the greater wax moth had a preponderant role, especially in the microbiological field, as demonstrated by the growing number of recent scientific publications. The reasons for its success must be sought in its peculiar characteristics such as the innate immune response mechanisms and the ability to grow at a temperature of 37°C. This review aims to describe the most relevant features of in microbiology, highlighting the most recent and relevant research on antibacterial strategies, novel drug tests and toxicological studies. Although solutions for some limitations are required, has all the necessary host features to be a consolidated model host.

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