The Likelihood of Developing a Carbapenem-Resistant Infection During a Hospital Stay

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2019 May 30

PMID 31138574

Citations 12

Authors

Pranita D Tamma

Abida Kazmi

Yehudit Bergman

Katherine E Goodman

Ernest Ekunseitan

Joe Amoah

Patricia J Simner

Affiliations

Soon will be listed here.

Abstract

Of 1,455 unique patients in U.S. intensive care units (ICUs), 4% were rectally colonized with CRE on admission. A total of 297 patients were initially negative for carbapenem-resistant (CRE) and remained in the ICU long enough to contribute additional swabs; 22% of these patients had a subsequent CRE-positive swab, with a median time to CRE colonization of 13 days (interquartile range, 7 to 21 days). Patients colonized with carbapenemase-producing CRE were more likely than those colonized with non-carbapenemase-producing CRE to develop CRE infections during their hospitalizations (36% versus 3%; < 0.05).

Citing Articles

Long-term Risk of Infection Among Patients Colonized With Antimicrobial-Resistant Pathogens: A Population-wide Cohort Study.

Blagojevic C, Brown K, Diong C, Fridman D, Johnstone J, Langford B Open Forum Infect Dis. 2024; 11(12):ofae712.

PMID: 39703788 PMC: 11656336. DOI: 10.1093/ofid/ofae712.

An analysis of differences in Carbapenem-resistant Enterobacterales in different regions: a multicenter cross-sectional study.

Guo B, Li P, Qin B, Wang S, Zhang W, Shi Y BMC Infect Dis. 2024; 24(1):116.

PMID: 38254025 PMC: 10804584. DOI: 10.1186/s12879-024-09005-9.

Clinical and Molecular Characteristics of Carbapenemase-Producing Strains from Patients with Biliary System Diseases and Hematological Malignancies.

Qian X, Bao W, Wu S, Zhou J, Yang Y, Wang X Infect Drug Resist. 2023; 16:7021-7028.

PMID: 38023410 PMC: 10631376. DOI: 10.2147/IDR.S430586.

Phenotypic and molecular characterization of beta-lactam resistant Multidrug-resistant Enterobacterales isolated from patients attending six hospitals in Northern Nigeria.

Medugu N, Tickler I, Duru C, Egah R, James A, Odili V Sci Rep. 2023; 13(1):10306.

PMID: 37365355 PMC: 10293160. DOI: 10.1038/s41598-023-37621-z.

Burden of severe infections due to carbapenem-resistant pathogens in intensive care unit.

Pace M, Corrente A, Passavanti M, Sansone P, Petrou S, Leone S World J Clin Cases. 2023; 11(13):2874-2889.

PMID: 37215420 PMC: 10198073. DOI: 10.12998/wjcc.v11.i13.2874.

References

McCann E, Srinivasan A, DeRyke C, Ye G, DePestel D, Murray J . Carbapenem-Nonsusceptible Gram-Negative Pathogens in ICU and Non-ICU Settings in US Hospitals in 2017: A Multicenter Study. Open Forum Infect Dis. 2018; 5(10):ofy241. PMC: 6194421. DOI: 10.1093/ofid/ofy241. View

Blackburn J, Tsimiklis C, Lavergne V, Pilotte J, Grenier S, Gilbert A . Carbapenem disks on MacConkey agar in screening methods for detection of carbapenem-resistant Gram-negative rods in stools. J Clin Microbiol. 2012; 51(1):331-3. PMC: 3536191. DOI: 10.1128/JCM.02878-12. View

Kesecioglu J, Eggimann P . What is new in selective decontamination of the digestive tract?. Intensive Care Med. 2015; 42(8):1270-5. PMC: 4930457. DOI: 10.1007/s00134-015-4009-5. View

Tamma P, Simner P . Phenotypic Detection of Carbapenemase-Producing Organisms from Clinical Isolates. J Clin Microbiol. 2018; 56(11). PMC: 6204673. DOI: 10.1128/JCM.01140-18. View

Simner P, Martin I, Opene B, Tamma P, Carroll K, Milstone A . Evaluation of Multiple Methods for Detection of Gastrointestinal Colonization of Carbapenem-Resistant Organisms from Rectal Swabs. J Clin Microbiol. 2016; 54(6):1664-1667. PMC: 4879269. DOI: 10.1128/JCM.00548-16. View

Tamma P, Hsu A . Defining the Role of Novel β-Lactam Agents That Target Carbapenem-Resistant Gram-Negative Organisms. J Pediatric Infect Dis Soc. 2019; 8(3):251-260. PMC: 6601385. DOI: 10.1093/jpids/piz002. View

McConville T, Sullivan S, Gomez-Simmonds A, Whittier S, Uhlemann A . Carbapenem-resistant Enterobacteriaceae colonization (CRE) and subsequent risk of infection and 90-day mortality in critically ill patients, an observational study. PLoS One. 2017; 12(10):e0186195. PMC: 5638409. DOI: 10.1371/journal.pone.0186195. View

Tamma P, Goodman K, Harris A, Tekle T, Roberts A, Taiwo A . Comparing the Outcomes of Patients With Carbapenemase-Producing and Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae Bacteremia. Clin Infect Dis. 2016; 64(3):257-264. PMC: 5241781. DOI: 10.1093/cid/ciw741. View

Wilson B, El Chakhtoura N, Patel S, Saade E, Donskey C, Bonomo R . Carbapenem-Resistant Enterobacter cloacae in Patients from the US Veterans Health Administration, 2006-2015. Emerg Infect Dis. 2017; 23(5):878-880. PMC: 5403041. DOI: 10.3201/eid2305.162034. View

10.

Davido B, Batista R, Michelon H, Lepainteur M, Bouchand F, Lepeule R . Is faecal microbiota transplantation an option to eradicate highly drug-resistant enteric bacteria carriage?. J Hosp Infect. 2017; 95(4):433-437. DOI: 10.1016/j.jhin.2017.02.001. View

11.

Martin-Loeches I, Diaz E, Valles J . Risks for multidrug-resistant pathogens in the ICU. Curr Opin Crit Care. 2014; 20(5):516-24. DOI: 10.1097/MCC.0000000000000124. View

12.

Weiner L, Webb A, Limbago B, Dudeck M, Patel J, Kallen A . Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2011-2014. Infect Control Hosp Epidemiol. 2016; 37(11):1288-1301. PMC: 6857725. DOI: 10.1017/ice.2016.174. View

13.

Guh A, Bulens S, Mu Y, Jacob J, Reno J, Scott J . Epidemiology of Carbapenem-Resistant Enterobacteriaceae in 7 US Communities, 2012-2013. JAMA. 2015; 314(14):1479-87. PMC: 6492240. DOI: 10.1001/jama.2015.12480. View

14.

Goodman K, Simner P, Klein E, Kazmi A, Gadala A, Toerper M . Predicting probability of perirectal colonization with carbapenem-resistant Enterobacteriaceae (CRE) and other carbapenem-resistant organisms (CROs) at hospital unit admission. Infect Control Hosp Epidemiol. 2019; 40(5):541-550. PMC: 6613376. DOI: 10.1017/ice.2019.42. View

15.

Shimasaki T, Seekatz A, Bassis C, Rhee Y, Yelin R, Fogg L . Increased Relative Abundance of Klebsiella pneumoniae Carbapenemase-producing Klebsiella pneumoniae Within the Gut Microbiota Is Associated With Risk of Bloodstream Infection in Long-term Acute Care Hospital Patients. Clin Infect Dis. 2018; 68(12):2053-2059. PMC: 6541703. DOI: 10.1093/cid/ciy796. View