Comparative Study of Breast Cancer with or Without Concomitant Paget Disease: An Analysis of the SEER Database

Overview

Journal Cancer Med

Specialty Oncology

Date 2019 May 29

PMID 31134761

Citations 13

Authors

Shijing Chen

Huaquan Chen

Ying Yi

Xuemei Jiang

Hai Lei

Xue Luo

Yu Chen

Sha Liu

Dan Yuan

Xinjian Jia

Junyan Li

Affiliations

Soon will be listed here.

Abstract

Background: Most mammary Paget disease (MPD) is associated with underlying in situ or invasive breast cancer. The objective of this study was to compare the clinicopathological characteristics and survival outcomes between breast cancer with Paget disease (PD) and breast cancer alone.

Methods: From the Surveillance, Epidemiology, and End Results (SEER) database, 2000-2015, of the US National Cancer Institute, we identified 1569 women who had PD with invasive ductal carcinoma (PD-IDC) and 1489 women who had PD with ductal carcinoma in situ (PD-DCIS). Independent demographic and clinicopathological variables as well as survival outcomes of these patients were compared to patients with the corresponding breast cancer without concomitant PD.

Results: PD-IDC and PD-DCIS both had worse survival outcomes and poorer tumor characteristics than the corresponding disease without PD. Contrary to in the breast cancer alone groups, in the breast cancer with PD groups, the HR status (P = 0.182 in PD-IDC and P = 0.371 in PD-DCIS), HER2 status (P = 0.788 in PD-IDC and P = 0.643 in PD-DCIS), and combined molecular subtype (P = 0.196 in PD-IDC and P = 0.853 in PD-DCIS) were not found to affect disease prognosis. After matching tumor characteristics and treatment approaches, PD-IDC as well as PD-DCIS exhibited no significant difference in disease prognosis with corresponding IDC and DCIS. Finally, by comparative analysis, a kind of PD-DCIS (ICD-O-3 code 8543/3) showed many invasive behaviors (31.8% of 8543/3 patients had stage I-III cancer) and was associated with worse survival outcomes than the other type of PD-DCIS.

Conclusions: Breast cancer with concomitant PD was associated with more aggressive tumor characteristics and worse survival outcomes. The HR status, HER2 status, and combined molecular subtype could not affect the prognosis of breast cancer with PD. Moreover, a portion of the PD-DCIS cases were invasive breast cancer cases that required special treatment.

Citing Articles

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Are there clinical and subclinical/pathological forms of Paget's disease of the breast?.

Pelorca R, de Oliveira-Junior I, Vieira R Front Oncol. 2023; 13:1287882.

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Qu J, Li C, Liu M, Wang Y, Sun S, Feng Z Am J Cancer Res. 2023; 13(10):4508-4530.

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HER2 Negative Mammary Paget's Disease or In Situ Melanoma? A Case Report and Review of the Literature.

Bosoteanu L, Aschie M, Orasanu C, Bosoteanu M Case Rep Pathol. 2023; 2023:1101130.

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Correlation analysis between androgen receptor and the clinicopathological features and prognosis of mammary Paget's disease.

Wu Y, Sun S, Huang Y, Xiao M, Zhao X, Lu X J Cancer Res Clin Oncol. 2022; 149(3):1175-1184.

PMID: 35364707 DOI: 10.1007/s00432-022-03988-1.

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