Synthetic Cell Division Via Membrane-transforming Molecular Assemblies

Overview

Journal BMC Biol

Publisher Biomed Central

Specialty Biology

Date 2019 May 26

PMID 31126285

Citations 23

Authors

Simon Kretschmer

Kristina A Ganzinger

Henri G Franquelim

Petra Schwille

Affiliations

Soon will be listed here.

Abstract

Reproduction, i.e. the ability to produce new individuals from a parent organism, is a hallmark of living matter. Even the simplest forms of reproduction require cell division: attempts to create a designer cell therefore should include a synthetic cell division machinery. In this review, we will illustrate how nature solves this task, describing membrane remodelling processes in general and focusing on bacterial cell division in particular. We discuss recent progress made in their in vitro reconstitution, identify open challenges, and suggest how purely synthetic building blocks could provide an additional and attractive route to creating artificial cell division machineries.

Citing Articles

Self-organized spatial targeting of contractile actomyosin rings for synthetic cell division.

Reverte-Lopez M, Kanwa N, Qutbuddin Y, Belousova V, Jasnin M, Schwille P Nat Commun. 2024; 15(1):10415.

PMID: 39614082 PMC: 11607352. DOI: 10.1038/s41467-024-54807-9.

Building Synthetic Cells─From the Technology Infrastructure to Cellular Entities.

Rothschild L, Averesch N, Strychalski E, Moser F, Glass J, Cruz Perez R ACS Synth Biol. 2024; 13(4):974-997.

PMID: 38530077 PMC: 11037263. DOI: 10.1021/acssynbio.3c00724.

Bacterial cell-size changes resulting from altering the relative expression of Min proteins.

Vashistha H, Jammal-Touma J, Singh K, Rabin Y, Salman H Nat Commun. 2023; 14(1):5710.

PMID: 37714867 PMC: 10504268. DOI: 10.1038/s41467-023-41487-0.

Engineering Tissue-Scale Properties with Synthetic Cells: Forging One from Many.

Lin A, Sihorwala A, Belardi B ACS Synth Biol. 2023; 12(7):1889-1907.

PMID: 37417657 PMC: 11017731. DOI: 10.1021/acssynbio.3c00061.

Binding and Characterization of DNA Origami Nanostructures on Lipid Membranes.

Khmelinskaia A, Schwille P, Franquelim H Methods Mol Biol. 2023; 2639:231-255.

PMID: 37166721 DOI: 10.1007/978-1-0716-3028-0_14.

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