Long Noncoding RNA in Preeclampsia: Transcriptional Noise or Innovative Indicators?

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2019 May 22

PMID 31111058

Citations 26

Authors

Xiuhua Yang

Tao Meng

Affiliations

Soon will be listed here.

Abstract

Preeclampsia (PE) is termed as an obstetric issue that is characterized by hypertension (≧140/90 mm Hg), together with proteinuria following 20 weeks of pregnancy. Until today, PE still constitutes a severe threat to the lives of both the mothers and fetuses. In the past, long noncoding RNAs (lncRNAs) were considered as the transcriptional noise. However, some investigations have indicated that lncRNAs could be used as innovative indicators in PE. The current review aims to discuss the relationship between lncRNAs and PE in recent years. According to the retrieved data, we concluded that lncRNAs can exert an impact on both the occurrence and development of PE through the changes in the biological functions of trophoblasts, immune regulation, epigenetic regulation, decidualization, and energy metabolism. The mechanisms of lncRNAs in PE will help us to better understand the pathogenesis of PE and help us to find targets for predicting and diagnosing PE in the future.

Citing Articles

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References

Pengjie Z, Xionghui C, Yueming Z, Ting X, Na L, Jianying T . LncRNA uc003fir promotes CCL5 expression and negatively affects proliferation and migration of trophoblast cells in preeclampsia. Pregnancy Hypertens. 2018; 14:90-96. DOI: 10.1016/j.preghy.2018.08.449. View

Yang Y, Xi L, Ma Y, Zhu X, Chen R, Luan L . The lncRNA small nucleolar RNA host gene 5 regulates trophoblast cell proliferation, invasion, and migration via modulating miR-26a-5p/N-cadherin axis. J Cell Biochem. 2018; 120(3):3173-3184. DOI: 10.1002/jcb.27583. View

Mercer T, Dinger M, Mattick J . Long non-coding RNAs: insights into functions. Nat Rev Genet. 2009; 10(3):155-9. DOI: 10.1038/nrg2521. View

Bartha J, Romero-Carmona R, Torrejon-Cardoso R, Comino-Delgado R . Insulin, insulin-like growth factor-1, and insulin resistance in women with pregnancy-induced hypertension. Am J Obstet Gynecol. 2002; 187(3):735-40. DOI: 10.1067/mob.2002.126283. View

Collins K . Physiological assembly and activity of human telomerase complexes. Mech Ageing Dev. 2007; 129(1-2):91-8. PMC: 2323683. DOI: 10.1016/j.mad.2007.10.008. View

Duley L . The global impact of pre-eclampsia and eclampsia. Semin Perinatol. 2009; 33(3):130-7. DOI: 10.1053/j.semperi.2009.02.010. View

Hung T, Wang Y, Lin M, Koegel A, Kotake Y, Grant G . Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nat Genet. 2011; 43(7):621-9. PMC: 3652667. DOI: 10.1038/ng.848. View

van Dijk M, Visser A, Buabeng K, Poutsma A, van der Schors R, Oudejans C . Mutations within the LINC-HELLP non-coding RNA differentially bind ribosomal and RNA splicing complexes and negatively affect trophoblast differentiation. Hum Mol Genet. 2015; 24(19):5475-85. DOI: 10.1093/hmg/ddv274. View

Hsu P, Santner-Nanan B, Dahlstrom J, Fadia M, Chandra A, Peek M . Altered decidual DC-SIGN+ antigen-presenting cells and impaired regulatory T-cell induction in preeclampsia. Am J Pathol. 2012; 181(6):2149-60. DOI: 10.1016/j.ajpath.2012.08.032. View

10.

Tsai J, Chi M, Schulte M, Moley K . The fatty acid beta-oxidation pathway is important for decidualization of endometrial stromal cells in both humans and mice. Biol Reprod. 2014; 90(2):34. PMC: 4435064. DOI: 10.1095/biolreprod.113.113217. View

11.

Geisler S, Coller J . RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts. Nat Rev Mol Cell Biol. 2013; 14(11):699-712. PMC: 4852478. DOI: 10.1038/nrm3679. View

12.

He X, He Y, Xi B, Zheng J, Zeng X, Cai Q . LncRNAs expression in preeclampsia placenta reveals the potential role of LncRNAs contributing to preeclampsia pathogenesis. PLoS One. 2013; 8(11):e81437. PMC: 3842959. DOI: 10.1371/journal.pone.0081437. View

13.

Ahmed R, Dunford J, Mehran R, Robson S, Kunadian V . Pre-eclampsia and future cardiovascular risk among women: a review. J Am Coll Cardiol. 2014; 63(18):1815-22. DOI: 10.1016/j.jacc.2014.02.529. View

14.

Tan Y, Xiao D, Xu Y, Wang C . Long non-coding RNA DLX6-AS1 is upregulated in preeclampsia and modulates migration and invasion of trophoblasts through the miR-376c/GADD45A axis. Exp Cell Res. 2018; 370(2):718-724. DOI: 10.1016/j.yexcr.2018.07.039. View

15.

Granger J, Alexander B, Llinas M, Bennett W, Khalil R . Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction. Hypertension. 2001; 38(3 Pt 2):718-22. DOI: 10.1161/01.hyp.38.3.718. View

16.

Fu G, Ye G, Nadeem L, Ji L, Manchanda T, Wang Y . MicroRNA-376c impairs transforming growth factor-β and nodal signaling to promote trophoblast cell proliferation and invasion. Hypertension. 2013; 61(4):864-72. DOI: 10.1161/HYPERTENSIONAHA.111.203489. View

17.

Trapnell C, Williams B, Pertea G, Mortazavi A, Kwan G, van Baren M . Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol. 2010; 28(5):511-5. PMC: 3146043. DOI: 10.1038/nbt.1621. View

18.

Brown C, Hendrich B, Rupert J, Lafreniere R, Xing Y, Lawrence J . The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell. 1992; 71(3):527-42. DOI: 10.1016/0092-8674(92)90520-m. View

19.

Wang J, Liu X, Wu H, Ni P, Gu Z, Qiao Y . CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer. Nucleic Acids Res. 2010; 38(16):5366-83. PMC: 2938198. DOI: 10.1093/nar/gkq285. View

20.

Djebali S, Davis C, Merkel A, Dobin A, Lassmann T, Mortazavi A . Landscape of transcription in human cells. Nature. 2012; 489(7414):101-8. PMC: 3684276. DOI: 10.1038/nature11233. View