Non-Coding RNAs in Preeclampsia-Molecular Mechanisms and Diagnostic Potential

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Oct 13

PMID 34638993

Citations 23

Authors

Jelena Munjas

Miron Sopic

Aleksandra Stefanovic

Rok Kosir

Ana Ninic

Ivana Joksic

Tamara Antonic

Vesna Spasojevic-Kalimanovska

Ursula Prosenc Zmrzljak

Affiliations

Soon will be listed here.

Abstract

Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality worldwide. Defects in trophoblast invasion, differentiation of extravillous trophoblasts and spiral artery remodeling are key factors in PE development. Currently there are no predictive biomarkers clinically available for PE. Recent technological advancements empowered transcriptome exploration and led to the discovery of numerous non-coding RNA species of which microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are the most investigated. They are implicated in the regulation of numerous cellular functions, and as such are being extensively explored as potential biomarkers for various diseases. Altered expression of numerous lncRNAs and miRNAs in placenta has been related to pathophysiological processes that occur in preeclampsia. In the following text we offer summary of the latest knowledge of the molecular mechanism by which lnRNAs and miRNAs (focusing on the chromosome 19 miRNA cluster (C19MC)) contribute to pathophysiology of PE development and their potential utility as biomarkers of PE, with special focus on sample selection and techniques for the quantification of lncRNAs and miRNAs in maternal circulation.

Citing Articles

Urinary miRNA Expression in Pre-Eclampsia During Early and Mid-Pregnancy.

Illarionov R, Maltseva A, Pachuliia O, Postnikova T, Vashukova E, Popova A Noncoding RNA. 2024; 10(6).

PMID: 39728606 PMC: 11677131. DOI: 10.3390/ncrna10060061.

The Hidden Relationship between Intestinal Microbiota and Immunological Modifications in Preeclampsia Pathogenesis.

Zambella E, Peruffo B, Guarano A, Inversetti A, Di Simone N Int J Mol Sci. 2024; 25(18).

PMID: 39337584 PMC: 11432041. DOI: 10.3390/ijms251810099.

Circulating extracellular vesicular microRNA signatures in early gestation show an association with subsequent clinical features of pre-eclampsia.

Ghosh S, Thamotharan S, Fong J, Lei M, Janzen C, Devaskar S Sci Rep. 2024; 14(1):16770.

PMID: 39039088 PMC: 11263608. DOI: 10.1038/s41598-024-64057-w.

Serum lncRNAs TUG1, H19, and NEAT1 and their target miR-29b/SLC3A1 axis as possible biomarkers of preeclampsia: Potential clinical insights.

Senousy M, Shaker O, Elmaasrawy A, Ashour A, Alsufyani S, Arab H Noncoding RNA Res. 2024; 9(4):995-1008.

PMID: 39026605 PMC: 11254728. DOI: 10.1016/j.ncrna.2024.06.007.

Unveiling immune tolerance pathways in preeclampsia placenta: implications for molecular targets and discovery of potential biomarkers.

Ma Y, Deng X, Shen R, Zhang H, Qian Y Front Endocrinol (Lausanne). 2024; 15:1385154.

PMID: 38894741 PMC: 11182985. DOI: 10.3389/fendo.2024.1385154.

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