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» Articles » PMID: 3110823

Strain Differences in Response to Drugs in the Tail Suspension Test for Antidepressant Activity

Overview
Journal Psychopharmacology (Berl)
Specialty Pharmacology
Date 1987 Jan 1
PMID 3110823
Citations 15
Authors
J A van der Heyden
E Molewijk
B Olivier
Affiliations
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Abstract

The effects of several types of antidepressants in a recently developed "behavioural despair" model, the tail-suspension test, are described. Drug effects on the automatically recorded duration of immobility and power of movements were measured in three strains of mice. Only in one strain (NMRI) did almost all antidepressants tested showed the expected reduction in duration of immobility. Tranquillizing drugs, but not stimulants, could be distinguished from antidepressants. The power of movements could not definitively be related to the pharmacological profile of the drugs tested. The use of the tail-suspension test as a rapid and highly predictive behavioural primary screen for antidepressant drugs is suggested.

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