Forced Swimming in Rats: Hypothermia, Immobility and the Effects of Imipramine

Overview

Journal Eur J Pharmacol

Specialty Pharmacology

Date 1979 Aug 15

PMID 258612

Citations 21

Authors

R D Porsolt

M Deniel

M JALFRE

Affiliations

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Abstract

Rats when forced to swim in a restricted space not only became immobile but showed marked hypothermia. The hypothermia was greater than that observed after reserpine or Ro 4-1284 and was not antagonized by imipramine at doses which significantly reduced immobility. Hypothermia induced by forced swimming can therefore be dissociated from the immobility occurring in these conditions and also from drug-induced hypothermia.

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