Non-classical B Cell Memory of Allergic IgE Responses

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2019 May 21

PMID 31105687

Citations 38

Authors

Sean P Saunders

Erica G M Ma

Carlos J Aranda

Maria A Curotto de Lafaille

Affiliations

Soon will be listed here.

Abstract

The long-term effectiveness of antibody responses relies on the development of humoral immune memory. Humoral immunity is maintained by long-lived plasma cells that secrete antigen-specific antibodies, and memory B cells that rapidly respond to antigen re-exposure by generating new plasma cells and memory B cells. Developing effective immunological memory is essential for protection against pathogens, and is the basis of successful vaccinations. IgE responses have evolved for protection against helminth parasites infections and against toxins, but IgE is also a potent mediator of allergic diseases. There has been a dramatic increase in the incidence of allergic diseases in recent decades and this has provided the impetus to study the nature of IgE antibody responses. As will be discussed in depth in this review, the IgE memory response has unique features that distinguish it from classical B cell memory.

Citing Articles

The Etiology of IgE-Mediated Food Allergy: Potential Therapeutics and Challenges.

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Changes in and Potential Mechanisms of Circulating IgA+CD27-Class-Switched Memory B Cells in Patients With Allergic Rhinitis.

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