» Articles » PMID: 31091849

MicroRNA-362-3p Attenuates Motor Deficit Following Spinal Cord Injury Via Targeting Paired Box Gene 2

Overview
Date 2019 May 17
PMID 31091849
Citations 28
Authors
Affiliations
Soon will be listed here.
Abstract

Spinal cord injury is a disabling disorder, leading to neurological impairments. Although some microRNAs have been reported to be associated with spinal cord injury, the function of microRNA-362-3p, as one of downregulated miRNAs after spinal cord injury, is still unclear. In current study, spinal cord injury models were established. Then, we performed microRNA-362-3p overexpression in spinal cord injury rats, which expressed the low microRNA-362-3p. Results from behavioral testing, hematoxylin and eosin staining and Nissl staining revealed that microRNA-362-3p over expresssion improved the functional resoration in spinal cord injury rats. Furthermore, it caused the decrease of neuronal apoptosis and inhibition of the neuronal inflammation in these rats. Besides, Paired box gene 2 was verified as a target gene of microRNA-362-3p using luciferase assay, which predicted via bioinformatics technology. Moreover, microRNA-362-3p alleviated the neuralgia and reduced the activation of ERK and p38 through inhibition of Paired box gene 2. In conclusion, the findings demonstrated that microRNA-362-3p attenuated neuropathic pain following spinal cord injury through targeting Paired box gene 2. It provides us the new biomarker to diagnose and monitor spinal cord injury.

Citing Articles

Astragaloside IV Inhibits Lung Injury and Fibrosis Induced by PM2.5 by Targeting RUNX1 Through miR-362-3p.

Tian H, Zhang Y, Li W, Xie G, Wu J, Liu J Mol Biotechnol. 2024; .

PMID: 39535691 DOI: 10.1007/s12033-024-01320-5.


The role of non-coding RNAs in neuropathic pain.

He X, Yang H, Zheng Y, Zhao X, Wang T Pflugers Arch. 2024; 476(11):1625-1643.

PMID: 39017932 DOI: 10.1007/s00424-024-02989-y.


Spinal Cord Injury: From MicroRNAs to Exosomal MicroRNAs.

Xu X, Liu R, Li Y, Zhang C, Guo C, Zhu J Mol Neurobiol. 2024; 61(8):5974-5991.

PMID: 38261255 DOI: 10.1007/s12035-024-03954-7.


β-Sitosterol Alleviates Neuropathic Pain by Affect Microglia Polarization through Inhibiting TLR4/NF-κB Signaling Pathway.

Zheng Y, Zhao J, Chang S, Zhuang Z, Waimei S, Li X J Neuroimmune Pharmacol. 2023; 18(4):690-703.

PMID: 38041701 DOI: 10.1007/s11481-023-10091-w.


Tetramethylpyrazine promotes angiogenesis and nerve regeneration and nerve defect repair in rats with spinal cord injury.

Hao Z, Yin C, Wang X, Huo Z, Zhang G, Jiang D Heliyon. 2023; 9(11):e21549.

PMID: 38027809 PMC: 10656251. DOI: 10.1016/j.heliyon.2023.e21549.