Structure and Nucleotide Sequence of a Drosophila Melanogaster Protein Kinase C Gene

Overview

Journal EMBO J

Specialties Biotechnology
Molecular Biology

Date 1987 Feb 1

PMID 3107983

Citations 26

Authors

A Rosenthal

L Rhee

R Yadegari

R Paro

A Ullrich

D V Goeddel

Affiliations

Soon will be listed here.

Abstract

Genomic and cDNA clones encoding a Drosophila melanogaster protein kinase C (PKC) homologue were identified using a bovine PKC cDNA probe. The cDNA clones contain a single open reading frame that encodes a 639 amino acid, 75-kd protein having extensive homology with bovine, human and rat PKC and homology with the kinase domains of other serine, threonine and tyrosine kinases. The Drosophila PKC gene is localized to region 53E of chromosome 2. The gene spans approximately 20 kb and contains at least 14 exons. Messenger RNA for PKC could not be detected in 0-3 h Drosophila embryos. Adult flies contain three PKC transcripts of 4.3, 4.0 and 2.4 kb.

Citing Articles

A conventional PKC critical for both the light-dependent and the light-independent regulation of the actin cytoskeleton in Drosophila photoreceptors.

Shieh B, Sun W, Ferng D J Biol Chem. 2023; 299(6):104822.

PMID: 37201584 PMC: 10318518. DOI: 10.1016/j.jbc.2023.104822.

Notch and PKC are involved in formation of the lateral region of the dorso-ventral axis in Drosophila embryos.

Tremmel D, Resad S, Little C, Wesley C PLoS One. 2013; 8(7):e67789.

PMID: 23861806 PMC: 3701627. DOI: 10.1371/journal.pone.0067789.

Transient receptor potential-like channels are essential for calcium signaling and fluid transport in a Drosophila epithelium.

MacPherson M, Pollock V, Kean L, Southall T, Giannakou M, Broderick K Genetics. 2005; 169(3):1541-52.

PMID: 15695363 PMC: 1449567. DOI: 10.1534/genetics.104.035139.

A Dictyostelium nuclear phosphatidylinositol phosphate kinase required for developmental gene expression.

Guo K, Nichol R, Skehel P, Dormann D, Weijer C, G Williams J EMBO J. 2001; 20(21):6017-27.

PMID: 11689442 PMC: 125292. DOI: 10.1093/emboj/20.21.6017.

14-3-3 proteins in neuronal development and function.

Skoulakis E, Davis R Mol Neurobiol. 1998; 16(3):269-84.

PMID: 9626666 DOI: 10.1007/BF02741386.

References

Payne M, Soderling T . Calmodulin-dependent glycogen synthase kinase. J Biol Chem. 1980; 255(17):8054-6. View

Parker P, Coussens L, Totty N, Rhee L, Young S, Chen E . The complete primary structure of protein kinase C--the major phorbol ester receptor. Science. 1986; 233(4766):853-9. DOI: 10.1126/science.3755547. View

Faletto D, Arrow A, Macara I . An early decrease in phosphatidylinositol turnover occurs on induction of Friend cell differentiation and precedes the decrease in c-myc expression. Cell. 1985; 43(1):315-25. DOI: 10.1016/0092-8674(85)90037-6. View

Michell R . Inositol phospholipids and cell surface receptor function. Biochim Biophys Acta. 1975; 415(1):81-47. DOI: 10.1016/0304-4157(75)90017-9. View

Kishimoto A, Takai Y, Mori T, Kikkawa U, NISHIZUKA Y . Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover. J Biol Chem. 1980; 255(6):2273-6. View

Macphee C, Drummond A, Otto A, JIMENEZ DE ASUA L . Prostaglandin F2 alpha stimulates phosphatidylinositol turnover and increases the cellular content of 1,2-diacylglycerol in confluent resting Swiss 3T3 cells. J Cell Physiol. 1984; 119(1):35-40. DOI: 10.1002/jcp.1041190107. View

Coughlin S, Lee W, Williams P, Giels G, Williams L . c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF. Cell. 1985; 43(1):243-51. DOI: 10.1016/0092-8674(85)90029-7. View

Teshima R, IKEBUCHI H, Terao T . Ca2+-dependent and phorbol ester activating phosphorylation of a 36K-dalton protein of rat basophilic leukemia cell membranes and immunoprecipitation of the phosphorylated protein with IgE-anti IgE system. Biochem Biophys Res Commun. 1984; 125(3):867-74. DOI: 10.1016/0006-291x(84)91363-9. View

Farrar W, Thomas T, Anderson W . Altered cytosol/membrane enzyme redistribution on interleukin-3 activation of protein kinase C. Nature. 1985; 315(6016):235-7. DOI: 10.1038/315235a0. View

10.

Kuo J, Andersson R, Wise B, Mackerlova L, Salomonsson I, Brackett N . Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine. Proc Natl Acad Sci U S A. 1980; 77(12):7039-43. PMC: 350436. DOI: 10.1073/pnas.77.12.7039. View

11.

Muller R, Bravo R, Burckhardt J, Curran T . Induction of c-fos gene and protein by growth factors precedes activation of c-myc. Nature. 1984; 312(5996):716-20. DOI: 10.1038/312716a0. View

12.

Cohen P, Burchell A, Foulkes J, Cohen P, Vanaman T, Nairn C . Identification of the Ca2+-dependent modulator protein as the fourth subunit of rabbit skeletal muscle phosphorylase kinase. FEBS Lett. 1978; 92(2):287-93. DOI: 10.1016/0014-5793(78)80772-8. View

13.

Weinberger C, Hollenberg S, Rosenfeld M, Evans R . Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product. Nature. 1985; 318(6047):670-2. DOI: 10.1038/318670a0. View

14.

Pouyssegur J, Chambard J, Franchi A, Paris S, Van Obberghen-Schilling E . Growth factor activation of an amiloride-sensitive Na+/H+ exchange system in quiescent fibroblasts: coupling to ribosomal protein S6 phosphorylation. Proc Natl Acad Sci U S A. 1982; 79(13):3935-9. PMC: 346550. DOI: 10.1073/pnas.79.13.3935. View

15.

Macara I . Oncogenes, ions, and phospholipids. Am J Physiol. 1985; 248(1 Pt 1):C3-11. DOI: 10.1152/ajpcell.1985.248.1.C3. View

16.

Kuo J, Greengard P . Cyclic nucleotide-dependent protein kinases. IV. Widespread occurrence of adenosine 3',5'-monophosphate-dependent protein kinase in various tissues and phyla of the animal kingdom. Proc Natl Acad Sci U S A. 1969; 64(4):1349-55. PMC: 223291. DOI: 10.1073/pnas.64.4.1349. View

17.

HOKIN L . Receptors and phosphoinositide-generated second messengers. Annu Rev Biochem. 1985; 54:205-35. DOI: 10.1146/annurev.bi.54.070185.001225. View

18.

NISHIZUKA Y . Studies and perspectives of protein kinase C. Science. 1986; 233(4761):305-12. DOI: 10.1126/science.3014651. View

19.

Knopf J, Lee M, Sultzman L, Kriz R, Loomis C, Hewick R . Cloning and expression of multiple protein kinase C cDNAs. Cell. 1986; 46(4):491-502. DOI: 10.1016/0092-8674(86)90874-3. View

20.

Streb H, Irvine R, Berridge M, Schulz I . Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature. 1983; 306(5938):67-9. DOI: 10.1038/306067a0. View