Transient Synaptic Potentiation in Nucleus Accumbens Shell During Refraining from Cocaine Seeking

Overview

Journal Addict Biol

Specialty Psychiatry

Date 2019 May 8

PMID 31062493

Citations 5

Authors

Douglas J Roberts-Wolfe

Jasper A Heinsbroek

Sade M Spencer

Ana Clara Bobadilla

Alexander C W Smith

Cassandra D Gipson

Peter W Kalivas

Affiliations

Soon will be listed here.

Abstract

Repeated exposure to drug-associated cues without reward (extinction) leads to refraining from drug seeking in rodents. We determined if refraining is associated with transient synaptic plasticity (t-SP) in nucleus accumbens shell (NAshell), akin to the t-SP measured in the NAcore during cue-induced reinstatement of drug seeking. Using whole cell patch electrophysiology, we found that medium spiny neurons (MSNs) in NAshell expressed increased ratio of AMPA to NMDA glutamate receptor currents during refraining, which normalized to baseline levels by the end of the 2-hour extinction session. Unlike t-SP observed in NAcore during reinstated drug seeking, neither dendrite spine head enlargement nor activation of matrix metalloproteases (MMP2/9) accompanied the increased AMPA:NMDA in NAshell during refraining. Refraining was also not associated with changes in paired pulse ratio, NMDA receptor current decay time, or AMPA receptor rectification index in NAshell MSNs. Our preliminary data in transgenic mice suggest that t-SP may increase D2-MSN inputs relative to D1-MSN inputs.

Citing Articles

Cell-type specific synaptic plasticity in dorsal striatum is associated with punishment-resistance compulsive-like cocaine self-administration in mice.

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Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens.

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Circuit selectivity in drug versus natural reward seeking behaviors.

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Cocaine and sucrose rewards recruit different seeking ensembles in the nucleus accumbens core.

Bobadilla A, Dereschewitz E, Vaccaro L, Heinsbroek J, Scofield M, Kalivas P Mol Psychiatry. 2020; 25(12):3150-3163.

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Psychostimulant-Induced Adaptations in Nucleus Accumbens Glutamatergic Transmission.

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