Validation of the Malay Version of Addenbrooke's Cognitive Examination III in Detecting Mild Cognitive Impairment and Dementia

Overview

Journal Dement Geriatr Cogn Dis Extra

Publisher Karger

Specialty Geriatrics

Date 2019 May 3

PMID 31043965

Citations 7

Authors

Kwai Ching Kan

Ponnusamy Subramaniam

Nortina Shahrizaila

Shahrul Bahyah Kamaruzzaman

Rosdinom Razali

Shazli Ezzat Ghazali

Affiliations

Soon will be listed here.

Abstract

Background/aims: This study aimed to investigate the validity and reliability of the Malay version of Addenbrooke's Cognitive Examination III (ACE-III) for detecting mild cognitive impairment (MCI) and dementia.

Methods: A total of 152 participants (dementia = 53, MCI = 38, controls = 61) were recruited from two teaching hospitals. The Malay version of ACE-III was translated following the standard guidelines for cross-cultural adaptation of measure. All the participants were assessed with the Malay version of ACE-III and Mini-Mental State Examination (MMSE).

Results: The reliability of the Malay version of ACE-III was good with Cronbach's α coefficient of 0.829 and intraclass correlation coefficient of 0.959. There was a strong positive correlation between the Malay version of ACE-III and MMSE ( = 0.806). Age ( = -0.335) and years of education ( = 0.536) exerted a significant correlation with total score performance. The cutoff score to discriminate dementia from healthy controls was 74/75 (sensitivity = 90.6%, specificity = 82.0%) whereas to discriminate MCI, the cutoff score was 77/78 (sensitivity = 63.2%, specificity = 63.9%). The diagnostic accuracy of ACE-III was higher than that of MMSE in the detection of dementia (area under the curve: ACE-III = 0.929 vs. MMSE = 0.915).

Conclusions: The Malay version of ACE-III demonstrated to be a reliable and valid screening tool for dementia.

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