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Feedback Control of Arterial Smooth Muscle Tone: the Role of Prostacyclin

Overview
Journal Br J Pharmacol
Publisher Wiley
Specialty Pharmacology
Date 1986 Dec 1
PMID 3101929
Citations 1
Authors
P Hadhazy
K Magyar
Affiliations
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Abstract

Indomethacin potentiated noradrenaline (NA)-induced contractions of rabbit isolated mesenteric arteries. Mechanical removal of the endothelium did not influence its potentiating effect. Prostacyclin (PGI2) synthesis was stimulated by NA (0.1-1.0 mumol l-1) and inhibited by indomethacin in a concentration-dependent manner. There was a positive correlation between the indomethacin-induced inhibition of PGI2 formation and the indomethacin-evoked potentiation of contractile responses to NA. These results suggest that endogenous PGI2 plays a part in the feedback control of vascular smooth muscle tone.

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PMID: 16012873 DOI: 10.1007/s00210-005-1065-3.

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