Antiobesity Effects of LMT1-48 Accompanied by Inhibition of in the Intestine of Diet-Induced Obese Mice

The gut microbiota is the most important environmental factor that plays a role in inducing obesity. The gram-negative bacteria, strains, recently identified in obese mice are considered to be pathogenic bacteria in the gut. Probiotics are important members of the gut microbiota and exert beneficial effects, including inhibiting the growth of potential pathogenic bacteria. Therefore, we isolated a total of 230 lactic acid bacteria from traditional, Korean fermented foods and fecal samples from newborn infants, including LMT1-48, which exhibited maximal antimicrobial activity against We next investigated the functional antiobesity effects of LMT1-48 in an -induced high-fat diet (HFD)-fed animal obesity model. To this end, the LMT1-48 showed antiobesity effects, including body weight loss and reduction of abdominal fat volume, which was accompanied by a decrease in leptin and total cholesterol levels in -induced HFD-fed mice. Notably, gut microbiota diversity also increased after long-term ingestion of LMT1-48, resulting in amelioration of obesity in -induced HFD-fed mice. Accordingly, results suggest that dietary intake of LMT1-48 protects against the onset of -induced obesity.