HECT E3 Ligases: A Tale With Multiple Facets

Overview

Journal Front Physiol

Date 2019 Apr 20

PMID 31001145

Citations 66

Authors

Janine Weber

Simona Polo

Elena Maspero

Affiliations

Soon will be listed here.

Abstract

Ubiquitination plays a pivotal role in several cellular processes and is critical for protein degradation and signaling. E3 ubiquitin ligases are the matchmakers in the ubiquitination cascade, responsible for substrate recognition. In order to achieve selectivity and specificity on their substrates, HECT E3 enzymes are tightly regulated and exert their function in a spatially and temporally controlled fashion in the cells. These characteristics made HECT E3s intriguing targets in drug discovery in the context of cancer biology.

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