Roles of Axon Guidance Molecules in Neuronal Wiring in the Developing Spinal Cord

Overview

Journal Nat Rev Neurosci

Specialty Neurology

Date 2019 Apr 20

PMID 31000796

Citations 60

Authors

Alain Chedotal

Affiliations

Soon will be listed here.

Abstract

The spinal cord receives, relays and processes sensory information from the periphery and integrates this information with descending inputs from supraspinal centres to elicit precise and appropriate behavioural responses and orchestrate body movements. Understanding how the spinal cord circuits that achieve this integration are wired during development is the focus of much research interest. Several families of proteins have well-established roles in guiding developing spinal cord axons, and recent findings have identified new axon guidance molecules. Nevertheless, an integrated view of spinal cord network development is lacking, and many current models have neglected the cellular and functional diversity of spinal cord circuits. Recent advances challenge the existing spinal cord axon guidance dogmas and have provided a more complex, but more faithful, picture of the ontogenesis of vertebrate spinal cord circuits.

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