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Early Stages of Motor Neuron Differentiation Revealed by Expression of Homeobox Gene Islet-1

Overview
Journal Science
Specialty Science
Date 1992 Jun 12
PMID 1350865
Citations 185
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Abstract

Motor neurons in the embryonic chick spinal cord express a homeobox gene, Islet-1, soon after their final mitotic division and before the appearance of other differentiated motor neuron properties. The expression of Islet-1 by neural cells is regulated by inductive signals from the floor plate and notochord. These results establish Islet-1 as the earliest marker of developing motor neurons. The molecular nature of the Islet-1 protein suggests that it may be involved in the establishment of motor neuron fate.

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