High Mobility Group Box 1 Enables Bacterial Lipids to Trigger Receptor-interacting Protein Kinase 3 (RIPK3)-mediated Necroptosis and Apoptosis in Mice

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2019 Apr 20

PMID 31000631

Citations 7

Authors

Ran Meng

Lan Gu

Yanyan Lu

Kai Zhao

Jianfeng Wu

Haichao Wang

Jiahuai Han

Yiting Tang

Ben Lu

Affiliations

Soon will be listed here.

Abstract

Receptor-interacting protein kinase 3 (RIPK3) is a key regulator of programmed cell death and inflammation during viral infection or sterile tissue injury. Whether and how bacterial infection also activates RIPK3-dependent immune responses remains poorly understood. Here we show that bacterial lipids (lipid IVa or lipid A) form a complex with high mobility group box 1 (HMGB1), released by activated immune cells or damaged tissue during bacterial infection, and that this complex triggers RIPK3- and TIR domain-containing adapter-inducing IFN-β (TRIF)-dependent immune responses. We found that these responses lead to macrophage death, interleukin (IL)-1α release, and IL-1β maturation. In an air-pouch inflammatory infiltration model, genetic deletion of , or IL-1 receptor (), or monoclonal antibody-mediated HMGB1 neutralization uniformly attenuated inflammatory responses induced by Gram-negative bacteria that release lipid IVa and lipid A. These findings uncover a previously unrecognized mechanism by which host factors and bacterial components work in concert to orchestrate immune responses.

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