Ectopic Dpp Signaling Promotes Stem Cell Competition Through EGFR Signaling in the Drosophila Testis

Overview

Journal Sci Rep

Specialty Science

Date 2019 Apr 18

PMID 30992503

Citations 5

Authors

Yanfen Lu

Yuncong Yao

Zhouhua Li

Affiliations

Soon will be listed here.

Abstract

Stem cell competition could select the fittest stem cells and potentially control tumorigenesis. However, little is known about the underlying molecular mechanisms. Here, we find that ectopic Decapentaplegic (Dpp) signal activation by expressing a constitutively active form of Thickveins (Tkv) in cyst stem cells (CySCs) leads to competition between CySCs and germline stem cells (GSCs) for niche occupancy and GSC loss. GSCs are displaced from the niche and undergo differentiation. Interestingly, we find that induction of Tkv results in elevated expression of vein, which further activates Epidermal Growth Factor Receptor (EGFR) signaling in CySCs to promote their proliferation and compete GSCs out of the niche. Our findings elucidate the important role of Dpp signaling in regulating stem cell competition and tumorigenesis, which could be shed light on tumorigenesis and cancer treatment in mammals.

Citing Articles

A regulatory loop of JAK/STAT signalling and its downstream targets represses cell fate conversion and maintains male germline stem cell niche homeostasis.

Kong R, Zhao H, Li J, Ma Y, Li N, Shi L Cell Prolif. 2024; 57(10):e13648.

PMID: 38987866 PMC: 11471429. DOI: 10.1111/cpr.13648.

Fasciclin 2 engages EGFR in an auto-stimulatory loop to promote imaginal disc cell proliferation in Drosophila.

Velasquez E, Gomez-Sanchez J, Donier E, Grijota-Martinez C, Cabedo H, Garcia-Alonso L PLoS Genet. 2022; 18(6):e1010224.

PMID: 35666718 PMC: 9203005. DOI: 10.1371/journal.pgen.1010224.

Auxilin regulates intestinal stem cell proliferation through EGFR.

Zhao H, Ren X, Kong R, Shi L, Li Z, Wang R Stem Cell Reports. 2022; 17(5):1120-1137.

PMID: 35427486 PMC: 9133653. DOI: 10.1016/j.stemcr.2022.03.010.

brinker levels regulated by a promoter proximal element support germ cell homeostasis.

Dunipace L, Newcomb S, Stathopoulos A Development. 2022; 149(3).

PMID: 35037688 PMC: 8918798. DOI: 10.1242/dev.199890.

FGF signaling promotes myoblast proliferation through activation of wingless signaling.

Vishal K, Lovato T, Bragg C, Chechenova M, M Cripps R Dev Biol. 2020; 464(1):1-10.

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