Wnt Ligands Regulate Tkv Expression to Constrain Dpp Activity in the Drosophila Ovarian Stem Cell Niche

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2015 May 27

PMID 26008746

Citations 41

Authors

Lichao Luo

Huashan Wang

Chao Fan

Sen Liu

Yu Cai

Affiliations

Soon will be listed here.

Abstract

Stem cell self-renewal versus differentiation is regulated by the niche, which provides localized molecules that favor self-renewal. In the Drosophila melanogaster female germline stem cell (GSC) niche, Decapentaplegic (Dpp), a fly transforming growth factor β molecule and well-established long-range morphogen, acts over one cell diameter to maintain the GSCs. Here, we show that Thickveins (Tkv; a type I receptor of Dpp) is highly expressed in stromal cells next to Dpp-producing cells and functions to remove excess Dpp outside the niche, thereby spatially restricting its activity. Interestingly, Tkv expression in these stromal cells is regulated by multiple Wnt ligands that are produced by the niche. Our data demonstrate a self-restraining mechanism by which the Drosophila ovarian GSC niche acts to define its own boundary.

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