Incident Mobility Disability, Mild Cognitive Impairment, and Mortality in Community-Dwelling Older Adults

Overview

Journal Neuroepidemiology

Specialties Neurology
Public Health

Date 2019 Apr 16

PMID 30986783

Citations 16

Authors

Lei Yu

Patricia A Boyle

Sue E Leurgans

Robert S Wilson

David A Bennett

Aron S Buchman

Affiliations

Soon will be listed here.

Abstract

Background/aims: Mobility disability and mild cognitive impairment (MCI) are common in aging and both are associated with risk of death. This study tested the hypothesis that risk of death differs by the order in which mobility disability and MCI occurred.

Methods: One thousand two hundred and sixty-two community-dwelling older adults were unimpaired at baseline and followed annually. Mobility disability was based on measured gait speed, and MCI was based on cognitive performance tests. A multistate Cox model simultaneously examined incidences of mobility disability and MCI to determine whether the order of their occurrence is differentially associated with risk of death.

Results: The average age was 75.3 years and 70% were female. While mobility disability occurred more frequently than incident MCI, the subsequent risk of death was higher in participants who developed MCI alone compared to those who developed mobility disability alone (hazard ratio [HR] 1.70, p = 0.018). Of the participants who initially developed mobility disability, about half subsequently developed MCI that doubled their risk of death (HR 2.17, p < 0.001). By contrast, over two-third who developed MCI subsequently developed mobility disability, which did not further increase their risk of death.

Conclusion: Mobility disability occurs more frequently in community-dwelling older adults, but MCI is more strongly associated with mortality.

Citing Articles

Temporal Sequence of Incident Mild Cognitive Impairment, Incident Parkinsonism, and Risk of Death in Unimpaired Community-Dwelling Older Adults.

Zammit A, Yu L, Oveisgharan S, Schneider J, Bennett D, Buchman A J Gerontol A Biol Sci Med Sci. 2024; 80(1.

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Benefits of a digital health technology for older nursing home residents. A de-novo cost-effectiveness model for digital health technologies to aid in the assessment of toileting and containment care needs.

Abraham K, Kanters T, Wagg A, Huige N, Hutt E, Al M PLoS One. 2024; 19(1):e0295846.

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Relation of Motor Impairments to Neuropathologic Changes of Limbic-Predominant Age-Related TDP-43 Encephalopathy in Older Adults.

Oveisgharan S, Yu L, Agrawal S, Nag S, Bennett D, Buchman A Neurology. 2023; 101(15):e1542-e1553.

PMID: 37604667 PMC: 10585698. DOI: 10.1212/WNL.0000000000207726.

Sarcopenia and Cognitive Decline in Older Adults: Targeting the Muscle-Brain Axis.

Arosio B, Calvani R, Ferri E, Coelho-Junior H, Carandina A, Campanelli F Nutrients. 2023; 15(8).

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Cognition and Mortality Risk Among Midlife and Older Americans.

Glei D, Mendes de Leon C, Lee C, Weinstein M J Gerontol A Biol Sci Med Sci. 2023; 78(7):1204-1211.

PMID: 36934331 PMC: 10329224. DOI: 10.1093/gerona/glad085.

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