Recent Advances in Dual Temperature Responsive Block Copolymers and Their Potential As Biomedical Applications

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2019 Apr 13

PMID 30974657

Citations 24

Authors

Yohei Kotsuchibashi

Mitsuhiro Ebara

Takao Aoyagi

Ravin Narain

Affiliations

Soon will be listed here.

Abstract

The development of stimuli responsive polymers has progressed significantly with novel preparation techniques, which has allowed access to new materials with unique properties. Dual thermoresponsive (double temperature responsive) block copolymers are particularly of interest as their properties can change depending on the lower critical solution temperature (LCST) or upper critical solution temperature (UCST) of each segment. For instance, these block copolymers can change from being hydrophilic, to amphiphilic or to hydrophobic simply by changing the solution temperature without any additional chemicals and the block copolymers can change from being fully solubilized to self-assembled structures to macroscopic aggregation/precipitation. Based on the unique solution properties, these dual thermo-responsive block copolymers are expected to be suitable for biomedical applications. This review is divided into three parts; LCST-LCST types of block copolymers, UCST-LCST types of block copolymers, and their potential as biomedical applications.

Citing Articles

Efficacy tumor therapeutic applications of stimuli-responsive block copolymer-based nano-assemblies.

Zhou J, Yang R, Chen Y, Chen D Heliyon. 2024; 10(7):e28166.

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Mechanically Tunable Hydrogels with Self-Healing and Shape Memory Capabilities from Thermo-Responsive Amino Acid-Derived Vinyl Polymers.

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Physicochemical Stimulus-Responsive Systems Targeted with Antibody Derivatives.

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Polymeric Micellar Systems-A Special Emphasis on "Smart" Drug Delivery.

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References

Luo S, Xu J, Zhu Z, Wu C, Liu S . Phase transition behavior of unimolecular micelles with thermoresponsive poly(N-isopropylacrylamide) coronas. J Phys Chem B. 2006; 110(18):9132-9. DOI: 10.1021/jp061055b. View

Weiss J, Laschewsky A . Temperature-induced self-assembly of triple-responsive triblock copolymers in aqueous solutions. Langmuir. 2011; 27(8):4465-73. DOI: 10.1021/la200115p. View

Roy D, Brooks W, Sumerlin B . New directions in thermoresponsive polymers. Chem Soc Rev. 2013; 42(17):7214-43. DOI: 10.1039/c3cs35499g. View

Amemori S, Kokado K, Sada K . Fundamental molecular design for precise control of thermoresponsiveness of organic polymers by using ternary systems. J Am Chem Soc. 2012; 134(20):8344-7. DOI: 10.1021/ja301688u. View

Akimoto J, Nakayama M, Okano T . Temperature-responsive polymeric micelles for optimizing drug targeting to solid tumors. J Control Release. 2014; 193:2-8. DOI: 10.1016/j.jconrel.2014.06.062. View

Toma M, Jonas U, Mateescu A, Knoll W, Dostalek J . Active Control of SPR by Thermoresponsive Hydrogels for Biosensor Applications. J Phys Chem C Nanomater Interfaces. 2013; 117(22):11705-11712. PMC: 3677233. DOI: 10.1021/jp400255u. View

Jochum F, Roth P, Kessler D, Theato P . Double thermoresponsive block copolymers featuring a biotin end group. Biomacromolecules. 2010; 11(9):2432-9. DOI: 10.1021/bm1006085. View

Zhang Y, Furyk S, Sagle L, Cho Y, Bergbreiter D, Cremer P . Effects of Hofmeister Anions on the LCST of PNIPAM as a Function of Molecular Weight. J Phys Chem C Nanomater Interfaces. 2008; 111(25):8916-8924. PMC: 2553222. DOI: 10.1021/jp0690603. View

Kolb H, Finn M, Sharpless K . Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Angew Chem Int Ed Engl. 2001; 40(11):2004-2021. DOI: 10.1002/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5. View

10.

Weaver J, Armes S, Butun V . Synthesis and aqueous solution properties of a well-defined thermo-responsive schizophrenic diblock copolymer. Chem Commun (Camb). 2002; (18):2122-3. DOI: 10.1039/b207251n. View

11.

Zhang H, Tong X, Zhao Y . Diverse thermoresponsive behaviors of uncharged UCST block copolymer micelles in physiological medium. Langmuir. 2014; 30(38):11433-41. DOI: 10.1021/la5026334. View

12.

Armand M, Endres F, MacFarlane D, Ohno H, Scrosati B . Ionic-liquid materials for the electrochemical challenges of the future. Nat Mater. 2009; 8(8):621-9. DOI: 10.1038/nmat2448. View

13.

Tian H, Yan J, Wang D, Gu C, You Y, Chen X . Synthesis of thermo-responsive polymers with both tunable UCST and LCST. Macromol Rapid Commun. 2011; 32(8):660-4. DOI: 10.1002/marc.201000713. View

14.

Leonforte F, Muller M . Poly(N-isopropylacrylamide)-Based Mixed Brushes: A Computer Simulation Study. ACS Appl Mater Interfaces. 2015; 7(23):12450-62. DOI: 10.1021/am5076309. View

15.

Techawanitchai P, Yamamoto K, Ebara M, Aoyagi T . Surface design with self-heating smart polymers for on-off switchable traps. Sci Technol Adv Mater. 2016; 12(4):044609. PMC: 5090495. DOI: 10.1088/1468-6996/12/4/044609. View

16.

Han X, Zhang X, Yin Q, Hu J, Liu H, Hu Y . Thermoresponsive diblock copolymer with tunable soluble-insoluble and soluble-insoluble-soluble transitions. Macromol Rapid Commun. 2013; 34(7):574-80. DOI: 10.1002/marc.201200785. View

17.

Zhang Z, Chao T, Chen S, Jiang S . Superlow fouling sulfobetaine and carboxybetaine polymers on glass slides. Langmuir. 2006; 22(24):10072-7. DOI: 10.1021/la062175d. View

18.

Mori T, Nakashima M, Fukuda Y, Minagawa K, Tanaka M, Maeda Y . Soluble-insoluble-soluble transitions of aqueous poly(N-vinylacetamide-co-acrylic acid) solutions. Langmuir. 2006; 22(9):4336-42. DOI: 10.1021/la060212v. View

19.

Kafer F, Liu F, Stahlschmidt U, Jerome V, Freitag R, Karg M . LCST and UCST in One: Double Thermoresponsive Behavior of Block Copolymers of Poly(ethylene glycol) and Poly(acrylamide-co-acrylonitrile). Langmuir. 2015; 31(32):8940-6. DOI: 10.1021/acs.langmuir.5b02006. View

20.

Cao Y, Zhao N, Wu K, Zhu X . Solution properties of a thermosensitive triblock copolymer of N-alkyl substituted acrylamides. Langmuir. 2009; 25(3):1699-704. DOI: 10.1021/la802971s. View