CORO1C Expression is Associated with Poor Survival Rates in Gastric Cancer and Promotes Metastasis In vitro

Overview

Journal FEBS Open Bio

Specialty Biology

Date 2019 Apr 12

PMID 30974047

Citations 23

Authors

Xiao Cheng

Xiaonan Wang

Zhengsheng Wu

Sheng Tan

Tao Zhu

Keshuo Ding

Affiliations

Soon will be listed here.

Abstract

Coronin-like actin-binding protein 1C (CORO1C) is a member of the WD repeat protein family that regulates actin-dependent processes by assembling F-actin. CORO1C was previously reported to promote metastasis in breast cancer and lung squamous cell carcinoma. Here, we investigated the role of CORO1C in gastric cancer. Higher expression levels of CORO1C were detected in gastric cancer tissues as compared with normal gastric tissues. In addition, CORO1C levels were found to be positively correlated with lymph node metastasis in gastric cancer patients. The expression levels of CORO1C were higher in stage III-IV gastric cancer patients (80.8%) than in stage I-II gastric cancer patients(57.1%). Gastric cancer patients positive for CORO1C expression showed lower relapse-free survival and overall survival rates. Knockdown of CORO1C dramatically suppressed total cell number, cell viability, cell colony formation, cell mitosis and cell metastasis, and promoted apoptosis of gastric cancer cells. Furthermore, cyclin D1 and vimentin were found to be positively regulated by CORO1C. As cyclin D1 and vimentin play an oncogenic role in gastric cancer, CORO1C may exert its tumor-promoting activity through these proteins.

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References

Ru Y, Chen X, Zhao Z, Zhang P, Feng S, Gao Q . CyclinD1 and p57 as biomarkers in differentiation, metastasis and prognosis of gastric cardia adenocarcinoma. Oncotarget. 2017; 8(43):73860-73870. PMC: 5650307. DOI: 10.18632/oncotarget.18008. View

Lim J, Shyamasundar S, Gunaratne J, Scully O, Matsumoto K, Bay B . YBX1 gene silencing inhibits migratory and invasive potential via CORO1C in breast cancer in vitro. BMC Cancer. 2017; 17(1):201. PMC: 5356414. DOI: 10.1186/s12885-017-3187-7. View

Liu P, Kang B, Wu Y, Sun J, Yen L, Fu T . Vimentin is a potential prognostic factor for tongue squamous cell carcinoma among five epithelial-mesenchymal transition-related proteins. PLoS One. 2017; 12(6):e0178581. PMC: 5453552. DOI: 10.1371/journal.pone.0178581. View

Rafiei E, Mohammadian-Hafshejani A, Towhidi F, Makhsosi B, Salehiniya H . Lack of Any Relationship of Stomach Cancer Incidence and Mortality with Development in Asia. Asian Pac J Cancer Prev. 2016; 17(8):3777-83. View

Li G, Wu X, Qian W, Cai H, Sun X, Zhang W . CCAR1 5' UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance. Cell Res. 2016; 26(6):655-73. PMC: 4897177. DOI: 10.1038/cr.2016.32. View

Zhao W, Yue L, Zhou F, Xu C, Liang W, Sui A . Clinical significance of vimentin expression and Her-2 status in patients with gastric carcinoma. Clin Transl Sci. 2013; 6(3):184-90. PMC: 5350850. DOI: 10.1111/cts.12043. View

Holmila R, Sklias A, Muller D, Esposti D, Guilloreau P, McKay J . Targeted deep sequencing of plasma circulating cell-free DNA reveals Vimentin and Fibulin 1 as potential epigenetic biomarkers for hepatocellular carcinoma. PLoS One. 2017; 12(3):e0174265. PMC: 5363871. DOI: 10.1371/journal.pone.0174265. View

Zhu S, He C, Deng S, Li X, Cui S, Zeng Z . MiR-548an, Transcriptionally Downregulated by HIF1α/HDAC1, Suppresses Tumorigenesis of Pancreatic Cancer by Targeting Vimentin Expression. Mol Cancer Ther. 2016; 15(9):2209-19. DOI: 10.1158/1535-7163.MCT-15-0877. View

Sun W, Guo F, Liu M . Up-regulated WDR5 promotes gastric cancer formation by induced cyclin D1 expression. J Cell Biochem. 2017; 119(4):3304-3316. DOI: 10.1002/jcb.26491. View

10.

Zhang H, Liu L, Wang Y, Zhao G, Xie R, Liu C . KLF8 involves in TGF-beta-induced EMT and promotes invasion and migration in gastric cancer cells. J Cancer Res Clin Oncol. 2013; 139(6):1033-42. DOI: 10.1007/s00432-012-1363-3. View

11.

Wang L, Zhang Y, Zhao L, Liu S, Yu S, Ma Y . MicroRNA-193b inhibits the proliferation, migration and invasion of gastric cancer cells via targeting cyclin D1. Acta Histochem. 2016; 118(4):323-30. DOI: 10.1016/j.acthis.2016.02.001. View

12.

Rosentreter A, Hofmann A, Xavier C, Stumpf M, Noegel A, Clemen C . Coronin 3 involvement in F-actin-dependent processes at the cell cortex. Exp Cell Res. 2007; 313(5):878-95. DOI: 10.1016/j.yexcr.2006.12.015. View

13.

Zhao L, Zhang P, Su X, Zhang B . The ubiquitin ligase TRIM56 inhibits ovarian cancer progression by targeting vimentin. J Cell Physiol. 2017; 233(3):2420-2425. DOI: 10.1002/jcp.26114. View

14.

Thal D, Xavier C, Rosentreter A, Linder S, Friedrichs B, Waha A . Expression of coronin-3 (coronin-1C) in diffuse gliomas is related to malignancy. J Pathol. 2008; 214(4):415-24. DOI: 10.1002/path.2308. View

15.

Ding K, Wu Z, Wang N, Wang X, Wang Y, Qian P . MiR-26a performs converse roles in proliferation and metastasis of different gastric cancer cells via regulating of PTEN expression. Pathol Res Pract. 2017; 213(5):467-475. DOI: 10.1016/j.prp.2017.01.026. View

16.

Ding K, Tan S, Huang X, Wang X, Li X, Fan R . GSE1 predicts poor survival outcome in gastric cancer patients by SLC7A5 enhancement of tumor growth and metastasis. J Biol Chem. 2018; 293(11):3949-3964. PMC: 5857990. DOI: 10.1074/jbc.RA117.001103. View

17.

Mataki H, Enokida H, Chiyomaru T, Mizuno K, Matsushita R, Goto Y . Downregulation of the microRNA-1/133a cluster enhances cancer cell migration and invasion in lung-squamous cell carcinoma via regulation of Coronin1C. J Hum Genet. 2014; 60(2):53-61. DOI: 10.1038/jhg.2014.111. View

18.

Ivaska J, Pallari H, Nevo J, Eriksson J . Novel functions of vimentin in cell adhesion, migration, and signaling. Exp Cell Res. 2007; 313(10):2050-62. DOI: 10.1016/j.yexcr.2007.03.040. View

19.

Yu J, Wang X, Lu Q, Wang J, Li L, Liao X . Extracellular 5'-nucleotidase (CD73) promotes human breast cancer cells growth through AKT/GSK-3β/β-catenin/cyclinD1 signaling pathway. Int J Cancer. 2017; 142(5):959-967. DOI: 10.1002/ijc.31112. View

20.

Chan K, Creed S, Bear J . Unraveling the enigma: progress towards understanding the coronin family of actin regulators. Trends Cell Biol. 2011; 21(8):481-8. PMC: 3163407. DOI: 10.1016/j.tcb.2011.04.004. View