CyclinD1 and P57 As Biomarkers in Differentiation, Metastasis and Prognosis of Gastric Cardia Adenocarcinoma

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Nov 2

PMID 29088752

Citations 12

Authors

Yi Ru

Xiao-Jie Chen

Zhi-Wei Zhao

Peng-Fei Zhang

Shuai-Hao Feng

Qiang Gao

She-Gan Gao

Xiao-Shan Feng

Affiliations

Soon will be listed here.

Abstract

Objective: This study aims to investigate the expression and significance of p57 and cyclinD1 in gastric cardia adenocarcinoma (GCA). p57 is a negative regulator in the cell cycle. On the contrary, cyclinD1 is a positive regulator of cell cycle progression.

Methods: Thirty-two cases of GCA tissues and adjacent non-cancerous tissues were collected for this study. Immunohistochemistry and fluorescence qualitative PCR was used to determine the level of p57 and cyclinD1 in GCA and its adjacent non-cancerous tissues. Furthermore, the correlation between the mRNA/protein and GCA clinical pathologic parameters were analyzed, and the relationship of p57 and cyclinD1 in GCA were also evaluated.

Results: The expression of p57 significantly lower in GCA ( = 0.036), and there was a significant correlation in the different degrees of differentiation ( < 0.05). Furthermore, median survival time was 41 months for patients with high mRNA expression of p57. This was longer compared to patients with low mRNA expression of P57 (37 months, X = 4.788, = 0.029).The expression of cyclinD1 was significantly higher in GCA( = 0.002), and was significant correlated to clinical stage(P<0.05). Median survival time was 34 months in patients with high mRNA expression of cyclinD1, which was shorter than in patients with low expression of cyclinD1 mRNA (41 months, X = 4.071, = 0.044). The protein expression of p57 was not correlated to the protein expression of cyclinD1 ( = 0.55).

Conclusion: The expression of p57 and cyclinD1 are likely to suppress or promote the tumorigenesis and progression of GCA.

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