Obstetric and Perinatal Outcomes of Dizygotic Twin Pregnancies Resulting from in Vitro Fertilization Versus Spontaneous Conception: a Retrospective Study

Overview

Journal PeerJ

Specialties Biology
Environmental Health
General Medicine

Date 2019 Apr 12

PMID 30972247

Citations 4

Authors

Hua Chen

Ying Wan

Haitao Xi

Weijue Su

Jing Cheng

Chunfang Zhu

Jieqiang Lv

Xinmei Wu

Junzhao Zhao

Affiliations

Soon will be listed here.

Abstract

This study was designed to to assess perinatal and neonatal outcomes of dizygotic twin pregnancies conceived naturally or by in vitro fertilization (IVF). After strict selection, the study included 470 dizygotic twin pregnancies. There were 249 resulting from IVF treatments and 221 conceiving spontaneously. After adjusting maternal age and primiparity, the results showed that there were no significant differences between the two groups ( > 0.05) in terms of maternal antenatal complications and neonatal outcomes. In conclusion, our study does not reveal increased risks for pregnancy-related complications and adverse neonatal outcomes in dizygotic twin pregnancies following IVF treatments. With these fundamental data, this study could provide a reference for perinatal care and clinical assisted reproductive technology (ART) treatment and help to inform infertile parents about the potential risks of IVF treatments.

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References

Lambalk C, Van Hooff M . Natural versus induced twinning and pregnancy outcome: a Dutch nationwide survey of primiparous dizygotic twin deliveries. Fertil Steril. 2001; 75(4):731-6. DOI: 10.1016/s0015-0282(01)01679-x. View

Reynolds M, Schieve L, Martin J, Jeng G, Macaluso M . Trends in multiple births conceived using assisted reproductive technology, United States, 1997-2000. Pediatrics. 2003; 111(5 Pt 2):1159-62. View

Nassar A, Usta I, Rechdan J, Harb T, Adra A, Abu-Musa A . Pregnancy outcome in spontaneous twins versus twins who were conceived through in vitro fertilization. Am J Obstet Gynecol. 2003; 189(2):513-8. DOI: 10.1067/s0002-9378(03)00485-x. View

Helmerhorst F, Perquin D, Donker D, Keirse M . Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. BMJ. 2004; 328(7434):261. PMC: 324454. DOI: 10.1136/bmj.37957.560278.EE. View

Penava D, Natale R . An association of chorionicity with preterm twin birth. J Obstet Gynaecol Can. 2004; 26(6):571-4. DOI: 10.1016/s1701-2163(16)30375-9. View

Rao A, Sairam S, Shehata H . Obstetric complications of twin pregnancies. Best Pract Res Clin Obstet Gynaecol. 2004; 18(4):557-76. DOI: 10.1016/j.bpobgyn.2004.04.007. View

McDonald S, Murphy K, Beyene J, Ohlsson A . Perinatal outcomes of in vitro fertilization twins: a systematic review and meta-analyses. Am J Obstet Gynecol. 2005; 193(1):141-52. DOI: 10.1016/j.ajog.2004.11.064. View

Kallen B, Finnstrom O, Lindam A, Nilsson E, Nygren K, Olausson P . Selected neonatal outcomes in dizygotic twins after IVF versus non-IVF pregnancies. BJOG. 2010; 117(6):676-82. DOI: 10.1111/j.1471-0528.2010.02517.x. View

Vasario E, Borgarello V, Bossotti C, Libanori E, Biolcati M, Arduino S . IVF twins have similar obstetric and neonatal outcome as spontaneously conceived twins: a prospective follow-up study. Reprod Biomed Online. 2010; 21(3):422-8. DOI: 10.1016/j.rbmo.2010.04.007. View

10.

Moini A, Shiva M, Arabipoor A, Hosseini R, Chehrazi M, Sadeghi M . Obstetric and neonatal outcomes of twin pregnancies conceived by assisted reproductive technology compared with twin pregnancies conceived spontaneously: a prospective follow-up study. Eur J Obstet Gynecol Reprod Biol. 2012; 165(1):29-32. DOI: 10.1016/j.ejogrb.2012.07.008. View

11.

Pinborg A, Wennerholm U, Romundstad L, Loft A, Aittomaki K, Soderstrom-Anttila V . Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis. Hum Reprod Update. 2012; 19(2):87-104. DOI: 10.1093/humupd/dms044. View

12.

Hansen M, Kurinczuk J, Milne E, de Klerk N, Bower C . Assisted reproductive technology and birth defects: a systematic review and meta-analysis. Hum Reprod Update. 2013; 19(4):330-53. DOI: 10.1093/humupd/dmt006. View

13.

Farhi A, Reichman B, Boyko V, Hourvitz A, Ron-El R, Lerner-Geva L . Maternal and neonatal health outcomes following assisted reproduction. Reprod Biomed Online. 2013; 26(5):454-61. DOI: 10.1016/j.rbmo.2013.01.014. View

14.

Anbazhagan A, Hunter A, Breathnach F, McAuliffe F, Geary M, Daly S . Comparison of outcomes of twins conceived spontaneously and by artificial reproductive therapy. J Matern Fetal Neonatal Med. 2013; 27(5):458-62. DOI: 10.3109/14767058.2013.818653. View

15.

Domingues A, Dinis S, Belo A, Couto D, Fonseca E, Moura P . Impact of induced pregnancies in the obstetrical outcome of twin pregnancies. Fertil Steril. 2013; 101(1):172-7. DOI: 10.1016/j.fertnstert.2013.09.026. View

16.

Caserta D, Bordi G, Stegagno M, Filippini F, Podagrosi M, Roselli D . Maternal and perinatal outcomes in spontaneous versus assisted conception twin pregnancies. Eur J Obstet Gynecol Reprod Biol. 2014; 174:64-9. DOI: 10.1016/j.ejogrb.2013.12.011. View

17.

Geisler M, OMahony A, Meaney S, Waterstone J, ODonoghue K . Obstetric and perinatal outcomes of twin pregnancies conceived following IVF/ICSI treatment compared with spontaneously conceived twin pregnancies. Eur J Obstet Gynecol Reprod Biol. 2014; 181:78-83. DOI: 10.1016/j.ejogrb.2014.07.033. View

18.

Qin J, Wang H, Sheng X, Liang D, Tan H, Xia J . Pregnancy-related complications and adverse pregnancy outcomes in multiple pregnancies resulting from assisted reproductive technology: a meta-analysis of cohort studies. Fertil Steril. 2015; 103(6):1492-508.e1-7. DOI: 10.1016/j.fertnstert.2015.03.018. View

19.

Vannuccini S, Clifton V, Fraser I, Taylor H, Critchley H, Giudice L . Infertility and reproductive disorders: impact of hormonal and inflammatory mechanisms on pregnancy outcome. Hum Reprod Update. 2015; 22(1):104-15. PMC: 7289323. DOI: 10.1093/humupd/dmv044. View

20.

Sun L, Zou G, Wei X, Chen Y, Zhang J, Okun N . Clinical outcomes after assisted reproductive technology in twin pregnancies: chorionicity-based comparison. Sci Rep. 2016; 6:26869. PMC: 4886640. DOI: 10.1038/srep26869. View