Fabrication of Multi-Layered Lidocaine and Epinephrine-Eluting PLGA/Collagen Nanofibers: In Vitro and In Vivo Study

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2019 Apr 11

PMID 30965721

Citations 6

Authors

Fu-Ying Lee

Demei Lee

Tzu-Chia Lee

Jan-Kan Chen

Ren-Chin Wu

Kuan-Chieh Liu

Shih-Jung Liu

Affiliations

Soon will be listed here.

Abstract

This study developed multi-layered lidocaine- and epinephrine-eluting biodegradable poly[(d,l)-lactide--glyco lide] (PLGA)/collagen nanofibers. An electrospinning technique was employed to fabricate the multi-layer biodegradable drug-eluting nanofibers. After fabrication, the nanofibrous membranes were characterized. The drug release characteristics were also investigated. In addition, the in vivo efficacy of nanofibers for pain relief and hemostasis in palatal oral wounds of rabbits were evaluated. Histological examinations were also completed. The experimental results suggested that all nanofibers exhibited good biocompatibility and eluted effective levels of lidocaine and epinephrine at the initial stages of wound recovery.

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