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Gut Microbiota Shifts in Pup Athymic BALB/c Mice: An Updated Identification in Nude Mice

Overview

Overview

Journal Animals (Basel)

Date 2019 Apr 11

PMID 30965569

Authors

Authors

Yuting Li

Hao Sun

Beibei Du

Hui Xu

Affiliations

Affiliations

Soon will be listed here.

Abstract

It is commonly recognized that immunodeficiency modifies the gut microbiota in mammals. However, little information on the gut microbiota is available for athymic nude mice; one of the most popular animals for modeling immunodeficiency and tumors. In this study, 16S rDNA amplicon sequencing was performed to investigate the gut microbial composition of pup nude BALB/c mice during a 30-day experimental period. In contrast to pup normal mice, pup nude mice showed a significant variation in gut microbiota. Continuously decreased dynamics of the gut bacterial Shannon index, abnormal Firmicutes/Bacteroidetes ratio, the rarity of Bifidobacterium and Lactobacillus species, and a developmental lag of gut bacterial functions were observed in nude mice. The shift in gut microbiota and abnormal colonization of beneficial bacterial species in nude mice provide an updated insight into the nude mouse tumor model and a new perspective for establishing an animal model for study on dysbacteriosis.

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