Children's Hospital of Philadelphia Score to Predict Severe Retinopathy in Indian Preterm Infants

Overview

Journal Eye (Lond)

Specialty Ophthalmology

Date 2019 Apr 10

PMID 30962544

Citations 4

Authors

Suraj Doshi

Saumil Desai

Ruchi Nanavati

Nandkishor Kabra

Snehal Martin

Affiliations

Soon will be listed here.

Abstract

Background: Retinopathy of Prematurity (ROP) screenings are expensive and entail heavy workload. Predictive models using postnatal weight gain reduces the number of ophthalmological examinations. The objective was to validate Children's Hospital of Philadelphia (CHOP) score to predict severe ROP in resource limited settings.

Methods: Prior to ophthalmic examination, the CHOP score was calculated to predict severe ROP (point estimate = 0.014) in 191 preterm infants. Cut-off point estimate, most suitable in resource limited settings was assessed.

Results: CHOP Score cutoff point (0.014) showed 67% sensitivity, 75% specificity. With CHOP score cut-off point (0.010), the corresponding values were 100% sensitivity, 51% specificity, PPV 12% and NPV 100%.

Conclusion: CHOP Score (0.014) is a poor tool to predict the onset of severe ROP. However, CHOP Score (0.010) is a promising tool to predict the onset of severe ROP and reduces the need for ophthalmological examinations by 50% in resource limited settings.

Citing Articles

Usefulness of Children's Hospital of Philadelphia ROP (CHOP ROP) model in the prediction of type 1 ROP.

Jain B, Sethi N, Sethi A, Arora R, Gupta T, Kaur H Indian J Ophthalmol. 2023; 71(11):3473-3477.

PMID: 37870009 PMC: 10752303. DOI: 10.4103/IJO.IJO_415_23.

Study to evaluate the relation between weight gain in infants and occurrence of retinopathy of prematurity.

Sethi N, Jain B, Gupta N, Singh S, Sethi G, Chadha C Indian J Ophthalmol. 2023; 71(3):890-894.

PMID: 36872704 PMC: 10229907. DOI: 10.4103/ijo.IJO_1538_22.

The Use of Postnatal Weight Gain Algorithms to Predict Severe or Type 1 Retinopathy of Prematurity: A Systematic Review and Meta-analysis.

Athikarisamy S, Desai S, Patole S, Rao S, Simmer K, Lam G JAMA Netw Open. 2021; 4(11):e2135879.

PMID: 34812847 PMC: 8611486. DOI: 10.1001/jamanetworkopen.2021.35879.

Diagnostic Accuracy of WINROP, CHOP-ROP and ROPScore in Detecting Type 1 Retinopathy of Prematurity.

Thomas D, Madathil S, Thukral A, Sankar M, Chandra P, Agarwal R Indian Pediatr. 2021; 58(10):915-921.

PMID: 34016801 PMC: 8549580.

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