Suppression of Obesity by an Intestinal Helminth Through Interactions with Intestinal Microbiota

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2019 Apr 10

PMID 30962398

Citations 15

Authors

Chikako Shimokawa

Seiji Obi

Mioko Shibata

Alex Olia

Takashi Imai

Kazutomo Suzue

Hajime Hisaeda

Affiliations

Soon will be listed here.

Abstract

Obesity is increasingly causing lifestyle diseases in developed countries where helminthic infections are rarely seen. Here, we investigated whether an intestinal nematode, , has a suppressive role in diet-induced obesity in mice. Infection with suppressed weight gain in obese mice, which was associated with increased uncoupling protein 1 (UCP1) expression in adipocytes and a higher serum norepinephrine (NE) concentration. Blocking interactions of NE with its receptor on adipocytes resulted in the failure to prevent weight gain and to enhance UCP1 expression in obese mice infected with , indicating that NE is responsible for the protective effects of on obesity. In addition to sympathetic nerve-derived NE, the intestinal microbiota was involved in the increase in NE. Infection with altered the composition of intestinal bacteria, and antibiotic treatment to reduce intestinal bacteria reversed the higher NE concentration, UCP1 expression, and prevention of the weight gain observed after infection. Our data indicate that exerts suppressive roles on obesity through modulation of microbiota that produce NE.

Citing Articles

Networking between helminths, microbes, and mammals.

Loke P, Harris N Cell Host Microbe. 2023; 31(4):464-471.

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Michla M, Wilhelm C Mucosal Immunol. 2022; 15(6):1234-1242.

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Administration of Hookworm Excretory/Secretory Proteins Improves Glucose Tolerance in a Mouse Model of Type 2 Diabetes.

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Helminth infection modulates number and function of adipose tissue Tregs in high fat diet-induced obesity.

Queiroz-Glauss C, Vieira M, Goncalves-Pereira M, Almeida S, Freire R, Gomes M PLoS Negl Trop Dis. 2022; 16(5):e0010105.

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Dai M, Yang X, Yu Y, Pan W Front Immunol. 2022; 13:827486.

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