Chemical Synthesis and Characterization of Poly(poly(ethylene Glycol) Methacrylate)-Grafted CdTe Nanocrystals Via RAFT Polymerization for Covalent Immobilization of Adenosine

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2019 Apr 10

PMID 30960061

Citations 1

Authors

Trinh Duy Nguyen

Hieu Vu-Quang

Thanh Sang Vo

Duy Chinh Nguyen

Dai-Viet N Vo

Dai Hai Nguyen

Kwon Taek Lim

Dai Lam Tran

Long Giang Bach

Affiliations

Soon will be listed here.

Abstract

This paper describes the functionalization of poly(poly(ethylene glycol) methacrylate) (PPEGMA)-grafted CdTe (PPEGMA--CdTe) quantum dots (QDs) via surface-initiated reversible addition⁻fragmentation chain transfer (SI-RAFT) polymerization for immobilization of adenosine. Initially, the hydroxyl-coated CdTe QDs, synthesized using 2-mercaptoethanol (ME) as a capping agent, were coupled with a RAFT agent, -benzyl '-trimethoxysilylpropyltrithiocarbonate (BTPT), through a condensation reaction. Then, 2,2'-azobisisobutyronitrile (AIBN) was used to successfully initiate in situ RAFT polymerization to generate PPEGMA--CdTe nanocomposites. Adenosine-above-PPEGMA-grafted CdTe (Ado--PPEGMA--CdTe) hybrids were formed by the polymer shell, which had successfully undergone bioconjugation and postfunctionalization by adenosine (as a nucleoside). Fourier transform infrared (FT-IR) spectrophotometry, energy-dispersive X-ray (EDX) spectroscopy, thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy results indicated that a robust covalent bond was created between the organic PPEGMA part, cadmium telluride (CdTe) QDs, and the adenosine conjugate. The optical properties of the PPEGMA--CdTe and Ado--PPEGMA--CdTe hybrids were investigated by photoluminescence (PL) spectroscopy, and the results suggest that they have a great potential for application as optimal materials in biomedicine.

Citing Articles

Monochelic Versus Telechelic Poly(Methyl Methacrylate) as a Matrix for Photoluminescent Nanocomposites with Quantum Dots.

Jablanovic A, Bekanova M, Litmanovich E, Karpov O, Bugakov M, Shandryuk G Molecules. 2021; 26(14).

PMID: 34299406 PMC: 8303834. DOI: 10.3390/molecules26144131.

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