Genetic Susceptibility in Head and Neck Squamous Cell Carcinoma in a Spanish Population

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2019 Apr 10

PMID 30959967

Citations 13

Authors

Javier Fernandez-Mateos

Raquel Seijas-Tamayo

Juan Carlos Adansa Klain

Miguel Pastor Borgonon

Elisabeth Perez-Ruiz

Ricard Mesia

Elvira Del Barco

Carmen Salvador Coloma

Antonio Rueda Dominguez

Javier Caballero Daroqui

Encarnacion Fernandez Ruiz

Alberto Ocana

Rogelio Gonzalez-Sarmiento

Juan Jesus Cruz-Hernandez

Affiliations

Soon will be listed here.

Abstract

Despite classical environmental risk factors like tobacco, alcohol or viral infection, not all individuals develop head and neck cancer. Therefore, identification of the genetic susceptibility produced by single nucleotide polymorphisms (SNPs) is an important task. A total of 296 human papillomavirus negative head and neck cancer (HNC) patients (126 laryngeal, 100 pharyngeal and 70 oral cavity) were included in the study, involving 29 candidate SNPs in genes within important carcinogenic pathways (oncogenesis and tumour suppression, DNA repair, inflammation, oxidation and apoptosis). Genotyping was performed using TaqMan probes or restriction fragment length assays in peripheral blood DNA. In addition, 259 paired controls were also evaluated with the same risk factors for each specific location. Nine SNPs in DNA repair ( rs11615, rs13181), inflammatory ( rs2069762, rs1800795), oxidative ( rs13035806 and rs2706110) and apoptotic genes ( rs1042522, rs2279744, rs2279115) were differently associated with HNSCC susceptibility by location. Some of these SNPs were not described before in this tumour type. In conclusion, we describe several SNPs associated with HNC in a Spanish population.

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