Javier Fernandez-Mateos
Overview
Explore the profile of Javier Fernandez-Mateos including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
1098
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0
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Recent Articles
1.
Fernandez-Mateos J, Cresswell G, Trahearn N, Webb K, Sakr C, Lampis A, et al.
Nat Cancer
. 2024 Jul;
5(9):1334-1351.
PMID: 38997466
Cancer evolution lays the groundwork for predictive oncology. Testing evolutionary metrics requires quantitative measurements in controlled clinical trials. We mapped genomic intratumor heterogeneity in locally advanced prostate cancer using 642...
2.
Bousquets-Munoz P, Molina O, Varela I, Alvarez-Eguiluz A, Fernandez-Mateos J, Gomez A, et al.
Leukemia
. 2024 May;
38(8):1808-1812.
PMID: 38806630
No abstract available.
3.
Chen B, Ramazzotti D, Heide T, Spiteri I, Fernandez-Mateos J, James C, et al.
Nat Commun
. 2023 Nov;
14(1):7827.
PMID: 38030613
The dominant mutational signature in colorectal cancer genomes is C > T deamination (COSMIC Signature 1) and, in a small subgroup, mismatch repair signature (COSMIC signatures 6 and 44). Mutations...
4.
Househam J, Heide T, Cresswell G, Spiteri I, Kimberley C, Zapata L, et al.
Nature
. 2022 Oct;
611(7937):744-753.
PMID: 36289336
Genetic and epigenetic variation, together with transcriptional plasticity, contribute to intratumour heterogeneity. The interplay of these biological processes and their respective contributions to tumour evolution remain unknown. Here we show...
5.
Heide T, Househam J, Cresswell G, Spiteri I, Lynn C, Mossner M, et al.
Nature
. 2022 Oct;
611(7937):733-743.
PMID: 36289335
Colorectal malignancies are a leading cause of cancer-related deathand have undergone extensive genomic study. However, DNA mutations alone do not fully explain malignant transformation. Here we investigate the co-evolution of...
6.
Llorente H, Perez-Rivera J, Perez-Nieto M, Cieza-Borrella C, Pastor I, Novo-Veleiro I, et al.
Mech Ageing Dev
. 2022 Jun;
206:111693.
PMID: 35760210
Telomere shortening is usually considered a biomarker of ageing. Harmful alcohol use promotes accelerated biological ageing and alcohol use disorders (AUDs) are associated with short telomere length (TL). This study...
7.
Smyth E, Vlachogiannis G, Hedayat S, Harbery A, Hulkki-Wilson S, Salati M, et al.
Gut
. 2020 Nov;
70(9):1632-1641.
PMID: 33199443
Objective: Epidermal growth factor receptor (EGFR) inhibition may be effective in biomarker-selected populations of advanced gastro-oesophageal adenocarcinoma (aGEA) patients. Here, we tested the association between outcome and copy number (CN)...
8.
Fernandez-Mateos J, Perez-Garcia J, Seijas-Tamayo R, Mesia R, Rubio-Casadevall J, Garcia-Giron C, et al.
Sci Rep
. 2020 Oct;
10(1):16634.
PMID: 33024167
234 diagnostic formalin-fixed paraffin-embedded (FFPE) blocks from homogeneously treated patients with locally advanced head and neck squamous cell carcinoma (HNSCC) within a multicentre phase III clinical trial were characterised. The...
9.
Acar A, Nichol D, Fernandez-Mateos J, Cresswell G, Barozzi I, Hong S, et al.
Nat Commun
. 2020 Apr;
11(1):1923.
PMID: 32317663
Drug resistance mediated by clonal evolution is arguably the biggest problem in cancer therapy today. However, evolving resistance to one drug may come at a cost of decreased fecundity or...
10.
Werner B, Case J, Williams M, Chkhaidze K, Temko D, Fernandez-Mateos J, et al.
Nat Commun
. 2020 Feb;
11(1):1035.
PMID: 32098957
Both normal tissue development and cancer growth are driven by a branching process of cell division and mutation accumulation that leads to intra-tissue genetic heterogeneity. However, quantifying somatic evolution in...