The Application of Omics Technologies to Study Axon Regeneration and CNS Repair

Overview

Journal F1000Res

Specialties Biomedical Engineering
Science

Date 2019 Apr 4

PMID 30941204

Citations 5

Authors

Andrea Tedeschi

Phillip G Popovich

Affiliations

Soon will be listed here.

Abstract

Traumatic brain and spinal cord injuries cause permanent disability. Although progress has been made in understanding the cellular and molecular mechanisms underlying the pathophysiological changes that affect both structure and function after injury to the brain or spinal cord, there are currently no cures for either condition. This may change with the development and application of multi-layer omics, new sophisticated bioinformatics tools, and cutting-edge imaging techniques. Already, these technical advances, when combined, are revealing an unprecedented number of novel cellular and molecular targets that could be manipulated alone or in combination to repair the injured central nervous system with precision. In this review, we highlight recent advances in applying these new technologies to the study of axon regeneration and rebuilding of injured neural circuitry. We then discuss the challenges ahead to translate results produced by these technologies into clinical application to help improve the lives of individuals who have a brain or spinal cord injury.

Citing Articles

Transplanting Neural Progenitor Cells into a Chronic Dorsal Column Lesion Model.

Hayakawa K, Jin Y, Bouyer J, Connors T, Otsuka T, Fischer I Biomedicines. 2022; 10(2).

PMID: 35203559 PMC: 8961783. DOI: 10.3390/biomedicines10020350.

Genes and miRNAs as Hurdles and Promoters of Corticospinal Tract Regeneration in Spinal Cord Injury.

Boido M, Vercelli A Front Cell Dev Biol. 2021; 9:748911.

PMID: 34722529 PMC: 8554128. DOI: 10.3389/fcell.2021.748911.

Axon growth and synaptic function: A balancing act for axonal regeneration and neuronal circuit formation in CNS trauma and disease.

Kiyoshi C, Tedeschi A Dev Neurobiol. 2020; 80(7-8):277-301.

PMID: 32902152 PMC: 7754183. DOI: 10.1002/dneu.22780.

Neuronal αδ proteins and brain disorders.

Ablinger C, Geisler S, Stanika R, Klein C, Obermair G Pflugers Arch. 2020; 472(7):845-863.

PMID: 32607809 PMC: 7351808. DOI: 10.1007/s00424-020-02420-2.

The stem cell marker promotes axon regeneration by down-regulating cholesterol synthesis via Smad signaling.

Lee J, Shin J, Lee B, Kim H, Jeon Y, Ahn S Proc Natl Acad Sci U S A. 2020; 117(27):15955-15966.

PMID: 32554499 PMC: 7355016. DOI: 10.1073/pnas.1920829117.

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