Synthetic Approaches to the New Drugs Approved During 2017

Overview

Journal J Med Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2019 Apr 3

PMID 30939001

Citations 9

Authors

Andrew C Flick

Carolyn A Leverett

Hong X Ding

Emma McInturff

Sarah J Fink

Christopher J Helal

Christopher J ODonnell

Affiliations

Soon will be listed here.

Abstract

New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide insight into molecular recognition while serving as leads for designing future new drugs. This annual review describes the most likely process-scale synthetic approaches to 31 new chemical entities approved for the first time globally in 2017.

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