Endogenous Non-retroviral Elements in Genomes of Aedes Mosquitoes and Vector Competence

Overview

Journal Emerg Microbes Infect

Specialty Infectious Diseases

Date 2019 Apr 3

PMID 30938223

Citations 29

Authors

Vincent Houe

Mariangela Bonizzoni

Anna-Bella Failloux

Affiliations

Soon will be listed here.

Abstract

Recent extensive (re)emergences of arthropod-borne viruses (arboviruses) such as chikungunya (CHIKV), zika (ZIKV) and dengue (DENV) viruses highlight the role of the epidemic vectors, Aedes aegypti and Aedes albopictus, in their spreading. Differences of vector competence to arboviruses highlight different virus/vector interactions. While both are highly competent to transmit CHIKV (Alphavirus,Togaviridae), only Ae. albopictus is considered as a secondary vector for DENV (Flavivirus, Flaviviridae). Among other factors such as environmental temperature, mosquito antiviral immunity and microbiota, the presence of non-retroviral integrated RNA virus sequences (NIRVS) in both mosquito genomes may modulate the vector competence. Here we review the current knowledge on these elements, highlighting the mechanisms by which they are produced and endogenized into Aedes genomes. Additionally, we describe their involvement in antiviral immunity as a stimulator of the RNA interference pathways and in some rare cases, as producer of viral-interfering proteins. Finally, we mention NIRVS as a tool for understanding virus/vector co-evolution. The recent discovery of endogenized elements shows that virus/vector interactions are more dynamic than previously thought, and genetic markers such as NIRVS could be one of the potential targets to reduce arbovirus transmission.

Citing Articles

Endogenous nege-like viral elements in arthropod genomes reveal virus-host coevolution and ancient history of two plant virus families.

Lu G, Ye Z, Qi Y, Lu J, Mao Q, Zhuo J J Virol. 2024; 98(10):e0099724.

PMID: 39212930 PMC: 11494950. DOI: 10.1128/jvi.00997-24.

Assessing pyrethroid resistance in Aedes aegypti from Cordoba Colombia: Implications of kdr mutations.

Atencia-Pineda M, Diaz-Ortiz D, Pareja-Loaiza P, Garcia-Leal J, Hoyos-Lopez R, Calderon-Rangel A PLoS One. 2024; 19(8):e0309201.

PMID: 39172980 PMC: 11340990. DOI: 10.1371/journal.pone.0309201.

A tangled threesome: understanding arbovirus infection in spp. and the effect of the mosquito microbiota.

Mantilla-Granados J, Castellanos J, Velandia-Romero M Front Microbiol. 2024; 14:1287519.

PMID: 38235434 PMC: 10792067. DOI: 10.3389/fmicb.2023.1287519.

Intrinsic factors driving mosquito vector competence and viral evolution: a review.

Lewis J, Gallichotte E, Randall J, Glass A, Foy B, Ebel G Front Cell Infect Microbiol. 2024; 13:1330600.

PMID: 38188633 PMC: 10771300. DOI: 10.3389/fcimb.2023.1330600.

Endogenous Viral Elements in Ixodid Tick Genomes.

Barnes M, Price D Viruses. 2023; 15(11).

PMID: 38005880 PMC: 10675110. DOI: 10.3390/v15112201.

References

Bosio C, Fulton R, Salasek M, Beaty B, Black 4th W . Quantitative trait loci that control vector competence for dengue-2 virus in the mosquito Aedes aegypti. Genetics. 2000; 156(2):687-98. PMC: 1461298. DOI: 10.1093/genetics/156.2.687. View

Bock M, Stoye J . Endogenous retroviruses and the human germline. Curr Opin Genet Dev. 2000; 10(6):651-5. DOI: 10.1016/s0959-437x(00)00138-6. View

Kapitonov V, Jurka J . Rolling-circle transposons in eukaryotes. Proc Natl Acad Sci U S A. 2001; 98(15):8714-9. PMC: 37501. DOI: 10.1073/pnas.151269298. View

Taylor G, Gao Y, Sanders D . Fv-4: identification of the defect in Env and the mechanism of resistance to ecotropic murine leukemia virus. J Virol. 2001; 75(22):11244-8. PMC: 114706. DOI: 10.1128/JVI.75.22.11244-11248.2001. View

Young Jr S, Samulski R . Adeno-associated virus (AAV) site-specific recombination does not require a Rep-dependent origin of replication within the AAV terminal repeat. Proc Natl Acad Sci U S A. 2001; 98(24):13525-30. PMC: 61074. DOI: 10.1073/pnas.241508998. View

Kumar S, Subramanian S . Mutation rates in mammalian genomes. Proc Natl Acad Sci U S A. 2002; 99(2):803-8. PMC: 117386. DOI: 10.1073/pnas.022629899. View

Jenkins G, Rambaut A, Pybus O, Holmes E . Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis. J Mol Evol. 2002; 54(2):156-65. DOI: 10.1007/s00239-001-0064-3. View

Batzer M, Deininger P . Alu repeats and human genomic diversity. Nat Rev Genet. 2002; 3(5):370-9. DOI: 10.1038/nrg798. View

Brown S . The fertile field of Drosophila Jak/STAT signalling. Curr Biol. 2002; 12(16):R569-75. DOI: 10.1016/s0960-9822(02)01057-6. View

10.

Holt R, Subramanian G, Halpern A, Sutton G, Charlab R, Nusskern D . The genome sequence of the malaria mosquito Anopheles gambiae. Science. 2002; 298(5591):129-49. DOI: 10.1126/science.1076181. View

11.

Failloux A, Vazeille M, Rodhain F . Geographic genetic variation in populations of the dengue virus vector Aedes aegypti. J Mol Evol. 2002; 55(6):653-63. DOI: 10.1007/s00239-002-2360-y. View

12.

Vazeille M, Rosen L, Mousson L, Failloux A . Low oral receptivity for dengue type 2 viruses of Aedes albopictus from Southeast Asia compared with that of Aedes aegypti. Am J Trop Med Hyg. 2003; 68(2):203-8. View

13.

Mattingly P . New records and a new species of the subgenus Stegomyia (Diptera, Culicidae) from the Ethiopian region. Ann Trop Med Parasitol. 1953; 47(3):294-8. DOI: 10.1080/00034983.1953.11685571. View

14.

McCLINTOCK B . Intranuclear systems controlling gene action and mutation. Brookhaven Symp Biol. 1956; (8):58-74. View

15.

Kotin R, Linden R, Berns K . Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination. EMBO J. 1992; 11(13):5071-8. PMC: 556985. DOI: 10.1002/j.1460-2075.1992.tb05614.x. View

16.

Kidwell M . Horizontal transfer. Curr Opin Genet Dev. 1992; 2(6):868-73. DOI: 10.1016/s0959-437x(05)80109-1. View

17.

SMITH C . The history of dengue in tropical Asia and its probable relationship to the mosquito Aedes aegypti. J Trop Med Hyg. 1956; 59(10):243-51. View

18.

Dillon R, Dillon V . The gut bacteria of insects: nonpathogenic interactions. Annu Rev Entomol. 2003; 49:71-92. DOI: 10.1146/annurev.ento.49.061802.123416. View

19.

Cancrini G, Romi R, Gabrielli S, Toma L, Paolo M, Scaramozzino P . First finding of Dirofilaria repens in a natural population of Aedes albopictus. Med Vet Entomol. 2003; 17(4):448-51. DOI: 10.1111/j.1365-2915.2003.00463.x. View

20.

Hanada K, Suzuki Y, Gojobori T . A large variation in the rates of synonymous substitution for RNA viruses and its relationship to a diversity of viral infection and transmission modes. Mol Biol Evol. 2004; 21(6):1074-80. PMC: 7107514. DOI: 10.1093/molbev/msh109. View