Analysis of Relationship Between Proteins from Plastid Genome of Red Alga Sp. (Japan) and Angiotensin I Converting Enzyme Inhibitory Peptides

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2019 Apr 3

PMID 30934583

Citations 11

Authors

Yuya Kumagai

Yoshikatsu Miyabe

Tomoyuki Takeda

Kohsuke Adachi

Hajime Yasui

Hideki Kishimura

Affiliations

Soon will be listed here.

Abstract

Plastid proteins are one of the main components in red algae. In order to clarify the angiotensin I converting enzyme (ACE) inhibitory peptides from red alga sp. (Japan), we determined the plastid genome sequence. The genome possesses 205 protein coding genes, which were classified as genetic systems, ribosomal proteins, photosystems, adenosine triphosphate (ATP) synthesis, metabolism, transport, or unknown. After comparing ACE inhibitory peptides between protein sequences and a database, photosystems (177 ACE inhibitory peptides) were found to be the major source of ACE inhibitory peptides (total of 751). Photosystems consist of phycobilisomes, photosystem I, photosystem II, cytochrome complex, and a redox system. Among them, photosystem I (53) and II (51) were the major source of ACE inhibitory peptides. We found that the amino acid sequence of apcE (14) in phycobilisomes, psaA (18) and psaB (13) in photosystem I, and psbB (11) and psbC (10) in photosystem II covered a majority of bioactive peptide sequences. These results are useful for evaluating the bioactive peptides from red algae.

Citing Articles

Preparation of β(1→3)/β(1→4) xylooligosaccharides from red alga dulse by two xylanases from Streptomyces thermogriseus.

Fujii Y, Kobayashi M, Miyabe Y, Kishimura H, Hatanaka T, Kumagai Y Bioresour Bioprocess. 2024; 8(1):38.

PMID: 38650209 PMC: 10991458. DOI: 10.1186/s40643-021-00390-6.

Understanding Antidiabetic Potential of Oligosaccharides from Red Alga Dulse Xylan by Investigating α-Amylase and α-Glucosidase Inhibition.

Mune Mune M, Hatanaka T, Kishimura H, Kumagai Y Molecules. 2024; 29(7).

PMID: 38611816 PMC: 11013419. DOI: 10.3390/molecules29071536.

Characterisation of Bioactive Peptides from Red Alga .

Mune Mune M, Miyabe Y, Shimizu T, Matsui W, Kumagai Y, Kishimura H Mar Drugs. 2023; 21(1).

PMID: 36662222 PMC: 9864793. DOI: 10.3390/md21010049.

Characterization of Antioxidant Activity of Heated Mycosporine-like Amino Acids from Red Alga Dulse in Japan.

Nishida Y, Saburi W, Miyabe Y, Kishimura H, Kumagai Y Mar Drugs. 2022; 20(3).

PMID: 35323483 PMC: 8954034. DOI: 10.3390/md20030184.

Characterization of ACE Inhibitory Peptides Prepared from Protein.

Kumagai Y, Toji K, Katsukura S, Morikawa R, Uji T, Yasui H Mar Drugs. 2021; 19(4).

PMID: 33916201 PMC: 8066288. DOI: 10.3390/md19040200.

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