Newly Identified T Cell Subsets in Mechanistic Studies of Food Immunotherapy

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2019 Apr 2

PMID 30932909

Citations 16

Authors

Vanitha Sampath

Kari C Nadeau

Affiliations

Soon will be listed here.

Abstract

Allergen-specific immunotherapy has shown promise for the treatment of food allergy and is currently being evaluated in clinical trials. Although immunotherapy can induce desensitization, the mechanisms underlying this process are not completely understood. Recent advances in high-throughput technologies along with concomitant advances in data analytics have enabled monitoring of cells at the single-cell level and increased the research focus on upstream cellular factors involved in the efficacy of immunotherapy, particularly the role of T cells. As our appreciation of different T cell subsets and their plasticity increases, the initial simplistic view that restoring Th1/Th2 balance by decreasing Th2 or increasing Th1 responses can ameliorate food allergy is being enhanced by a more complex model involving other T cell subsets, particularly Tregs. In this Review, we focus on the current understanding of T cell functions in food allergy, tolerance, and immunotherapy.

Citing Articles

Amelioration Effect of ZW3 on Ovalbumin-Induced Allergic Symptoms in BALB/c Mice.

Xu H, Duan X, Wang Y, Geng W Foods. 2025; 14(1.

PMID: 39796306 PMC: 11720023. DOI: 10.3390/foods14010016.

Clinical and immunological outcomes after randomized trial of baked milk oral immunotherapy for milk allergy.

Dantzer J, Lewis S, Psoter K, Sutherland A, Frazier A, Richardson E JCI Insight. 2025; 10(1.

PMID: 39782691 PMC: 11721308. DOI: 10.1172/jci.insight.184301.

Allergen-Encapsulating Nanoparticles Reprogram Pathogenic Allergen-Specific Th2 Cells to Suppress Food Allergy.

Saunders M, Rad L, Williams L, Landers J, Urie R, Hocevar S Adv Healthc Mater. 2024; 14(5):e2400237.

PMID: 38691819 PMC: 11527797. DOI: 10.1002/adhm.202400237.

Immune signatures predicting the clinical outcome of peanut oral immunotherapy: where we stand.

Wanniang N, Boehm T, Codreanu-Morel F, Divaret-Chauveau A, Assugeni I, Hilger C Front Allergy. 2023; 4:1270344.

PMID: 37849958 PMC: 10577271. DOI: 10.3389/falgy.2023.1270344.

Identification of cow milk epitopes to characterize and quantify disease-specific T cells in allergic children.

Lewis S, Sutherland A, Soldevila F, Westernberg L, Aoki M, Frazier A J Allergy Clin Immunol. 2023; 152(5):1196-1209.

PMID: 37604312 PMC: 10846667. DOI: 10.1016/j.jaci.2023.07.020.

References

Vander Leek T, Liu A, Stefanski K, Blacker B, Bock S . The natural history of peanut allergy in young children and its association with serum peanut-specific IgE. J Pediatr. 2000; 137(6):749-55. DOI: 10.1067/mpd.2000.109376. View

Abarbanel D, Seki S, Davies Y, Marlen N, Benavides J, Cox K . Immunomodulatory effect of vancomycin on Treg in pediatric inflammatory bowel disease and primary sclerosing cholangitis. J Clin Immunol. 2012; 33(2):397-406. PMC: 3565076. DOI: 10.1007/s10875-012-9801-1. View

Branum A, Lukacs S . Food allergy among children in the United States. Pediatrics. 2009; 124(6):1549-55. DOI: 10.1542/peds.2009-1210. View

Cukrowska B . Microbial and Nutritional Programming-The Importance of the Microbiome and Early Exposure to Potential Food Allergens in the Development of Allergies. Nutrients. 2018; 10(10). PMC: 6212882. DOI: 10.3390/nu10101541. View

Chiang D, Chen X, Jones S, Wood R, Sicherer S, Burks A . Single-cell profiling of peanut-responsive T cells in patients with peanut allergy reveals heterogeneous effector T2 subsets. J Allergy Clin Immunol. 2018; 141(6):2107-2120. PMC: 5994177. DOI: 10.1016/j.jaci.2017.11.060. View

Pellerin L, Jenks J, Chinthrajah S, Dominguez T, Block W, Zhou X . Peanut-specific type 1 regulatory T cells induced in vitro from allergic subjects are functionally impaired. J Allergy Clin Immunol. 2017; 141(1):202-213.e8. DOI: 10.1016/j.jaci.2017.05.045. View

Sampath V, Sindher S, Zhang W, Nadeau K . New treatment directions in food allergy. Ann Allergy Asthma Immunol. 2018; 120(3):254-262. PMC: 5978756. DOI: 10.1016/j.anai.2018.01.004. View

Grief S . Food Allergies. Prim Care. 2016; 43(3):375-91. DOI: 10.1016/j.pop.2016.04.008. View

Berin M . Pathogenesis of IgE-mediated food allergy. Clin Exp Allergy. 2015; 45(10):1483-96. DOI: 10.1111/cea.12598. View

10.

Gupta R, Warren C, Smith B, Jiang J, Blumenstock J, Davis M . Prevalence and Severity of Food Allergies Among US Adults. JAMA Netw Open. 2019; 2(1):e185630. PMC: 6324316. DOI: 10.1001/jamanetworkopen.2018.5630. View

11.

Su Y, Romeu-Bonilla E, Anagnostou A, Fitz-Patrick D, Hearl W, Heiland T . Safety and long-term immunological effects of CryJ2-LAMP plasmid vaccine in Japanese red cedar atopic subjects: A phase I study. Hum Vaccin Immunother. 2017; 13(12):2804-2813. PMC: 5718801. DOI: 10.1080/21645515.2017.1329070. View

12.

Burks A, Wood R, Jones S, Sicherer S, Fleischer D, Scurlock A . Sublingual immunotherapy for peanut allergy: Long-term follow-up of a randomized multicenter trial. J Allergy Clin Immunol. 2015; 135(5):1240-8.e1-3. PMC: 4527157. DOI: 10.1016/j.jaci.2014.12.1917. View

13.

Soller L, Ben-Shoshan M, Harrington D, Fragapane J, Joseph L, St Pierre Y . Overall prevalence of self-reported food allergy in Canada. J Allergy Clin Immunol. 2012; 130(4):986-8. DOI: 10.1016/j.jaci.2012.06.029. View

14.

Josefowicz S, Niec R, Kim H, Treuting P, Chinen T, Zheng Y . Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature. 2012; 482(7385):395-9. PMC: 3485072. DOI: 10.1038/nature10772. View

15.

Varshney P, Jones S, Scurlock A, Perry T, Kemper A, Steele P . A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response. J Allergy Clin Immunol. 2011; 127(3):654-60. PMC: 3060783. DOI: 10.1016/j.jaci.2010.12.1111. View

16.

Lin D, Maecker H . Mass Cytometry Assays for Antigen-Specific T Cells Using CyTOF. Methods Mol Biol. 2017; 1678:37-47. PMC: 5798871. DOI: 10.1007/978-1-4939-7346-0_3. View

17.

Berin M, Shreffler W . Mechanisms Underlying Induction of Tolerance to Foods. Immunol Allergy Clin North Am. 2015; 36(1):87-102. DOI: 10.1016/j.iac.2015.08.002. View

18.

Calzada D, Baos S, Cremades L, Cardaba B . New Treatments for Allergy: Advances in Peptide Immunotherapy. Curr Med Chem. 2017; 25(19):2215-2232. DOI: 10.2174/0929867325666171201114353. View

19.

Kostadinova A, Willemsen L, Knippels L, Garssen J . Immunotherapy - risk/benefit in food allergy. Pediatr Allergy Immunol. 2013; 24(7):633-44. DOI: 10.1111/pai.12122. View

20.

Chinthrajah R, Purington N, Sampath V, Andorf S, Manohar M, Prunicki M . High dimensional immune biomarkers demonstrate differences in phenotypes and endotypes in food allergy and asthma. Ann Allergy Asthma Immunol. 2018; 121(1):117-119.e1. PMC: 6026562. DOI: 10.1016/j.anai.2018.04.022. View