Prenatal and Postnatal Inflammation-related Risk Factors for Retinopathy of Prematurity

Overview

Journal J Perinatol

Specialty Gynecology & Obstetrics

Date 2019 Apr 2

PMID 30932029

Citations 24

Authors

Gregory P Goldstein

Stephanie A Leonard

Peiyi Kan

Euna B Koo

Henry C Lee

Suzan L Carmichael

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the relationship between prenatal and postnatal inflammation-related risk factors and severe retinopathy of prematurity (ROP).

Study Design: The study included infants born <30 weeks in California from 2007 to 2011. Multivariable log-binomial regression was used to assess the association between prenatal and postnatal inflammation-related exposures and severe ROP, defined as stage 3-5 or surgery for ROP.

Results: Of 14,816 infants, 10.8% developed severe ROP. Though prenatal inflammation-related risk factors were initially associated with severe ROP, after accounting for the effect of these risk factors on gestational age at birth through mediation analysis, the association was non-significant (P = 0.6). Postnatal factors associated with severe ROP included prolonged oxygen exposure, sepsis, intraventricular hemorrhage, and necrotizing enterocolitis.

Conclusion: Postnatal inflammation-related factors were associated with severe ROP more strongly than prenatal factors. The association between prenatal inflammation-related factors and ROP was explained by earlier gestational age in infants exposed to prenatal inflammation.

Citing Articles

Predicting Retinopathy of Prematurity Risk Using Plasma Levels of Insulin-like Growth Factor 1 (IGF1), Tumor Necrosis Factor-Alpha (TNF-Alpha), and Neonatal Parameters.

Cioboata D, Costescu O, Manea A, Doandes F, Zaharie M, Popa Z Clin Pract. 2024; 14(4):1515-1528.

PMID: 39194926 PMC: 11353236. DOI: 10.3390/clinpract14040122.

The relationship between inflammatory markers and retinopathy of prematurity in extremely premature infants.

Bektas F, Guclu E, Simsek H, Akcali M Graefes Arch Clin Exp Ophthalmol. 2024; 263(1):69-76.

PMID: 39172162 DOI: 10.1007/s00417-024-06604-9.

Predictive value of serum inflammatory markers in retinopathy of prematurity.

Kiran Yenice E, Kara C, Karsli Turkoglu T, Ulubas Isik D, Celik I Eye (Lond). 2024; 38(14):2822-2826.

PMID: 39054383 PMC: 11427560. DOI: 10.1038/s41433-024-03260-5.

Early-Onset Sepsis as an Early Predictor for Retinopathy of Prematurity: A Meta-analysis.

El Emrani S, van der Meeren L, Jansen E, Goeman J, Termote J, Lopriore E Am J Perinatol. 2024; 42(3):387-394.

PMID: 39029916 PMC: 11793952. DOI: 10.1055/a-2369-6690.

Retinopathy of prematurity screening: prevalence and risk factors of ophthalmic complications in non-treated preterm infants.

Strelnikov J, Rao R, Majidi S, Lueder G, Lee A, Reynolds M Eye (Lond). 2024; 38(8):1462-1470.

PMID: 38212403 PMC: 11126400. DOI: 10.1038/s41433-023-02921-1.

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