Evaluating Retinopathy of Prematurity Screening Guidelines for 24- to 27-week Gestational Age Infants

Overview

Journal J Perinatol

Specialty Gynecology & Obstetrics

Date 2014 Feb 8

PMID 24503911

Citations 8

Authors

K A Kennedy

L A Wrage

R D Higgins

N N Finer

W A Carlo

M C Walsh

A R Laptook

R G Faix

B A Yoder

K Schibler

M G Gantz

A Das

N S Newman

D L Phelps

Affiliations

Soon will be listed here.

Abstract

Objective: To determine whether current retinopathy of prematurity (ROP) screening guidelines adequately identify treatable ROP in a contemporary cohort of extremely low gestation infants.

Study Design: Data from the Surfactant, Positive Pressure, and Pulse Oximetry Randomized Trial were used. Inborn infants of 24 (0)/7 to 27 (6)/7 weeks gestational age (GA) with consent before delivery were enrolled in 2005 to 2009. Severe ROP (type 1 ROP or treatment with laser, cryotherapy or bevacizumab) or death was the primary outcome for the randomized trial. Examinations followed the then current AAP (American Academy of Pediatrics) screening recommendations, beginning by 31 to 33 weeks postmenstrual age (PMA).

Result: One thousand three hundred and sixteen infants were enrolled in the trial. Nine hundred and ninety-seven of the 1121 who survived to first eye exam had final ROP outcome determined. One hundred and thirty-seven (14% of 997) met criteria for severe ROP and 128 (93%) of those had sufficient data (without missing or delayed exams) to determine age of onset of severe ROP. PMA at onset was 32.1 to 53.1 weeks. In this referral center cohort, 1.4% (14/997) developed severe ROP after discharge.

Conclusion: Our contemporary data support the 2013 AAP screening guidelines for ROP for infants of 24 (0)/7 to 27 (6)/7 weeks GA. Some infants do not meet treatment criteria until after discharge home. Post-discharge follow-up of infants who are still at risk for severe ROP is crucial for timely detection and treatment.

Citing Articles

[Interpretation of the UK screening and treatment of retinopathy of prematurity updated 2022 guidelines].

Dong X, Li J, Luo K, Tang J, Mu D Zhongguo Dang Dai Er Ke Za Zhi. 2024; 26(5):437-443.

PMID: 38802901 PMC: 11135053. DOI: 10.7499/j.issn.1008-8830.2311073.

Autonomic measures identify stress, pain, and instability associated with retinopathy of prematurity ophthalmologic examinations.

Onuagu V, Gardner F, Soni A, Doheny K Front Pain Res (Lausanne). 2022; 3:1032513.

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National guideline for ophthalmological screening of premature infants in Germany (S2k level, AWMF guidelines register no. 024/010, March 2020) : Joint recommendation of the German Ophthalmological Society (DOG), German Retina Society (RG),....

Maier R, Hummler H, Kellner U, Krohne T, Lawrenz B, Lorenz B Ophthalmologie. 2022; 119(Suppl 2):123-136.

PMID: 35507084 DOI: 10.1007/s00347-022-01632-4.

[Guidelines for ophthalmological screening of premature infants in Germany (S2k level, AWMF guidelines register no. 024/010, March 2020) : Joint recommendation of the German Ophthalmological Society (DOG), Retinological Society (RG), Professional...].

Maier R, Hummler H, Kellner U, Krohne T, Lawrenz B, Lorenz B Ophthalmologe. 2021; 118(Suppl 2):117-131.

PMID: 33694101 DOI: 10.1007/s00347-021-01353-0.

Achieved oxygen saturations and retinopathy of prematurity in extreme preterms.

Gantz M, Carlo W, Finer N, Rich W, Faix R, Yoder B Arch Dis Child Fetal Neonatal Ed. 2019; 105(2):138-144.

PMID: 31229956 PMC: 6925651. DOI: 10.1136/archdischild-2018-316464.

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